Necrotizing vasculitis

Chamouard JM, Smadja D et al (1993) [Neuropathy caused by necrotizing vasculitis in HIV-1 infection]. Rev Neurol (Paris) 149(5) 358-361... 

Galassi G, Gentilini M et al (1998) Motor neuron disease and HIV-1 infection in a 30-year-old HIV-positive heroin abuser a causal relationship Clin Neuropathol 17(3) 131-135 Gherardi R, Lebargy F et al (1989) Necrotizing vasculitis and HIV replication in peripheral nerves. N Engl J Med 321(10) 685-686... 

Churg-Strauss syndrome A systemic necrotizing vasculitis with prominent lung involvement including severe asthma and eosinophilia. 

Park KE, Chipps DR, Benson EM. Necrotizing vasculitis secondary to propylthiouracil presenting as purpura fulmi-nans. Rheumatology (Oxford) 1999 38(8) 790—2. 

Sams, W. M., Claman, H. N., Kohler, P. F., McIntosh, R. M., Small, P., and Mass, M. F., Human necrotizing vasculitis Immunoglobulin and complement in vessel walls of cutaneous lesions and normal skin. J. Invest. Dermatol. 64, 441-445 (1975). 

In a 56-year-old man with a transitional cell carcinoma of the bladder gemcitabine plus cisplatin caused extensive necrotizing vasculitis with muscle damage after the second course of therapy (20). Chemotherapy was withdrawn immediately but the symptoms of... 

Leukocytoclastic vasculitis is a well-described and confirmed adverse effect of G-CSF, as documented in several reports, with recurrence after renewed administration of G-CSF (SEDA-19,343). Most cases were confined to the skin, and renal insufficiency with hematuria and proteinuria was noted in only very few patients. Based on 18 cases reported in the hterature or to the manufacturers, vasculitis was thought to have occurred in 6% of patients with chronic benign neutropenia, but in only six of about 200 000 patients with mahgnant disease (68). Vasculitis usually developed when the neutrophil count rose above 800 X 10 /1, suggesting that an increase in neutrophil count may play a role in necrotic vasculitis. Against this background, the occurrence of vascuhtis is not considered as treatment-hmiting and does not preclude further G-CSF administration if the absolute neutrophil count is lower than 1000 x 10 /1. 

Couderc LJ, Philippe B, Franck N, Balloul-Delclaux E, Lessana-Leibowitch M. Necrotizing vasculitis and... 

The lupus-like syndrome (SED-9, 318) with hydralazine occurs particularly in slow acetylators (and only rarely in fast acetylators) and in patients with the HLA-DR4 antigen. Blood dyscrasias and necrotizing vasculitis are additional features. 

In the treatment of rheumatoid arthritis leflunomide can cause a vasculitis, and acute necrotizing vasculitis is rare but serious (47,86). 

Necrotizing vasculitis of the skin and uterine cervix has been reported in a patient taking minocycline (49). 

Generalized reactions (26) include cutaneous necrotizing vasculitis (SEDA-5, 106) (SEDA-17, 113), nephritis, paralytic ileus, and angiitis with cutaneous, muscular, articular, and renal involvement (21). 

Penicillamine has no direct effect on the cardiovascular system. However, penicillamine-associated polymyositis can involve cardiac muscle and cause dysrhythmias, Adams-Stokes attacks, and death. Necrotizing vasculitis can occur as an immunological reaction to penicillamine... 

Two patients have been described with the internuclear ophthalmoplegia syndrome, probably induced by penicillamine. In one it was secondary to serious progressive intracerebral necrotizing vasculitis (46), in the other the underlying condition was a myasthenic reaction (84). Isolated cases have been described of neuromyotonia (85) and diffuse fasciculations (86), attributed to penicillamine. 

A rash or photosensitivity can also occur as part of the penicillamine-induced lupus-like syndrome (248-250). Type II bullous systemic lupus erythematosus (251) and necrotizing vasculitis (46) have been attributed to penicillamine. In one report, a hypersensitivity reaction to penicillamine with a skin rash and fever was associated with low back pain (252). 

Evans syndrome Churg-Strauss syndrome Necrotizing vasculitis Guillain-Barre syndrome... 

Jaffe lA. The treatment of rheumatoid arthritis and necrotizing vasculitis with penicillamine. Arthritis Rheum 1970 13 436-443. 

Banfi G, Imbasciati E, Guerra E, Mihatsch MJ, PonticelliC. Extracapillary glomerulonephritis with necrotizing vasculitis in D-peni-cillamine treated patients with rheumatoid arthritis. Nephron 1983 33 56-60. 

Byornberg A, Gesslen H.Thiazides a cause of necrotizing vasculitis. Lancet 1965 2 982. 

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