Sp3 transcription factor

Zelko, IN. Folz, RJ. (2004). Spl and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase. Free Radio Biol Med, Vol. 37, No. 8, pp. 1256-1271, ISSN 0891-5849. 

Transcription regulators are also known to be sumoylated. One of tbe early studies of tbis phenomenon showed that promyelocytic leukemia protein (PML) is a substrate for SUMO conjugation. Once SUMO is attached to the PML protein it is directed to a subdomain of tbe nucleus called tbe PML oncogenic domain (POD). It is thought that POD localization of the PML protein allows it to recruit other proteins such as transcription factors. Transcription factors in the POD can activate or inhibit transcription. Another transcription factor known to be sumoylated is Sp3. ° SUMO also has roles in chromatin condensation and interphase chromosome organization. ... 

Betunilic acid (ALS- 357) (65) Oncology Inhibits transcription factor specificity protein-1 (Spl), Sp3, and Sp4 activation Phase I Advanced Life Sciences (UIC) 574-576... 

In overview, the hypoxia-sensitive expression of each of these kinds of proteins (EPO, PGK, and LDH), and of other glycolytic enzymes appears to be two-step or two-cycle systems (figure 3.14) the first cycles involve the constitutive expression of key hypoxia-sensitive transcription factors such as HIF 1 and Sp3, while the second cycles of gene expression are mediated by these transcription factors and regulate the biosynthesis of EPO, PGK, LDH, other glycolytic enzymes, and other hypoxia-sensitive gene products. 

Lee J, Kosaras B, Aleyasin H, Han JA, Park DS, et al. 2006. Role of cyclooxygenase-2 induction by transcription factor Spl and Sp3 in neuronal oxidative and DNA damage response. FASEB J 20 E1657-E1669. 

Ryu H, Lee J, Zaman K, Kubilis J, Ferrante RJ, et al. 2003. Spl and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons. J Neurosci 23 3597-3606. 

Biotin affects cell signaling by transcription factors such as cGMP, NF-kB, Spl and Sp3, receptor tyrosine kinases by calcium, nitric oxide, the biotin intermediate biotinyl-5 -adenosine monophosphate (biotinyl-5 -AMP), microRNAs (miRs) and by HLCS-dependent signaling. Biotin also affects gene expression at the posttranscriptional level (Collins et al., 1988), which is not the focus of this chapter. 

GRIFFIN, J. B., RODRIGUEZ-MELENDEZ, R., ZEMPLENI, J. (2003) The nuclear abundance of transcription factors Spl and Sp3 depends on biotin in Jurkat cells. J. Nutr, 133, 3409-3415. 

Zelko, IN. Mueller, MR. Folz, RJ. (2008). Transcription factors spl and sp3 regulate expression of human extracellular superoxide dismutase in lung fibroblasts. Am J Respir Cell Mol Biol, Vol. 39, No. 2, pp.243-251, ISSN 1044-1549. 

Conn, K. J., Rich, C. B., Jensen, D. E., Fontanilla, M. R., Bashir, M. M., Rosenbloom, J., and Foster, J. A. (1996). Insulin-like growth factor-I regulates transcription of the elastin gene through a putative retinoblastoma control element. A role for Sp3 acting as a repressor of elastin gene transcription. / Biol. Chem. 271, 28853-28860. 

With the human CYP17A1 gene, the homeo-domain protein Pbxl was shown to interact with protein kinase A in the cyclic AMP-dependent regulation (at —250/—241) . Further analysis showed interaction at a cyclic AMP-related site (-80/-40) by SF-1 (ref [1228]). Further, interactions were shown for Spl and Sp3 (-227/-184) and NF-IC (-107/-85 and — 178/—152). SF-1 vide supra) also interacts with p54", NonO, and protein-associated splicing factor °. The ACTH/cyclic AMP response is dependent upon phosphatase activity, as well as kinase activity - The cyclic AMP-dep)end-ent protein kinase enhances transcription via MKP-1 activation, involving phosphorylation of SF-1 (ref [1233]). 

T. Kamataki (2001). Novel transcriptional regulation of the human CYP3A7 gene by Spl and Sp3 through nuclear factor KB-like element. J. Biol. Chem. 276, 38010-38022. 

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