Solvent method capsule preparation

In a variation of the above process, a water soluble monomer A is adsorbed on water-immiscible solvent droplets dispersed in the aqueous solution of A and then polymerized to form closed shell structure. For example, cross-linked polysaccharide capsules with diameters ranging from 200 nm to several microns and wall thicknesses of several tens of nanometers have been fabricated by interfacial polymerization of methacrylated N,N-diethylaminoethyl dextran (DdexMA) [212]. In a typical method of preparation of DdexMA (see Figure 5.85), a mixture of N,N-diethylaminoethyl dextran (Ddex),... 

This method is known as solvent method for the preparation of low dose capsules, and is further described in Sect. 4.5.1. The method brings about not only particle size reduction and deagglomeration but is also used for the preparation of triturations of low-dose active substances (see also Sect. 29.1.8). 

For some capsule preparations in pharmacies ordered mixing may be the case. Mixing as the result of the solvent method may be considered as such (Sect. 4.5.1). 

SOP F08-4 1 Capsules with low dosage, preparation by solvent method ... 

Per dosage form list aU applied methods of preparation (such as capsule filling after dry mixing or using the solvent method). 

The next two chapters concern nanostructured core particles. Chapter 13 provides examples of nano-fabrication of cored colloidal particles and hollow capsules. These systems and the synthetic methods used to prepare them are exceptionally adaptable for applications in physical and biological fields. Chapter 14, discusses reversed micelles from the theoretical viewpoint, as well as their use as nano-hosts for solvents and drugs and as carriers and reactors. 

A rapid, simple, and specific TLC method has been developed for the estimation of panthenol and pantothenic acid in pharmaceutical preparations containing other vitamins, amino acids, symps, enzymes, etc. " The vitamin was extracted with ethanol (from tablets and capsules) or benzyl alcohol (from liquid oral preparations) and isolated from other ingredients by TLC on silica gel 60 plates with 2-propanol-water (85 15 vol/vol) as a solvent. p-Alanine (panthothenate) or p-alanol (panthenol) was liberated by heating for 20 min at 160°C. The liberated amines were visualized with the ninhydrin reaction and estimated by spectrodensitometry at 490 nm. Recoveries for panthenol and pantothenic acid were 99.8 2.25% and 100.2 1.7%, respectively. 

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