Solute carrier superfamily

SLC2 (solute carrier) superfamily consists of 12 glucose transporters (GLUT1-12) and one H+-myo-inositol cotransporter (HMIT or GLUT13). They all have 12 transmembrane segments with the N- and C-termini both on the cytoplasmic aspect and a specific N-linked oligosaccharide side-chain on either the first or fourth extracellular loop. 

Other Transporters Also of importance for CNS pharmacogenomics are transporters encoded by genes of the solute carrier superfamily (SLC) and solute carrier organic (SLCO) transporter family, responsible for the... 

The Na +/taurocholate cotransport system Ntcp belongs to the "solute carrier superfamily (SLC) and represents one of the best-studied transport proteins in the basolateral membrane. It transports taurocholate and other conjugated bile acids from the blood into hepatocytes. In addition, an ontogenetically presumably older and Na-independent protein (Oatpl) is expressed in the basolateral membrane. 

Families in the Human Solute Carrier Superfamily (Continued) ... 

To date more than 400 membrane proteins have been annotated in the human genome. Two major superfamilies - which are also intensively investigated in our group - are the ATP- binding cassette transporters (ABC, e.g. P-glycoprotein), and the solute carrier superfamily (SLC). They will be discussed into more detail in section 3 of this chapter. 

Figure 15.1 Schematic illustration of the extended phase concept during drug elimination in the kidney and liver. Phase 0 = uptake of drugs from the blood into the hepatocytes or proximal tubule epithelial cells. This uptake is mediated by transport proteins belonging to the SLC (solute carrier) transporter superfamily. Phase I and...

Oatps/OATPs are multispecific sodium-independent transport proteins. They comprise at least 36 members of human, rat, mouse, and some nonmammalian species. On the basis of their phylogenetic relationships, all rodent and human Oatps/OATPs so far identified within the OATP/SLCO superfamily of solute carriers have been classified into 6 families and 13 subfamilies (Figure 3.1) 2]. 

The ATP-Bhiding Cassette (ABC) and Solute Carrier (SLC) Genetic Superfamilies, 267... 

Carrier-mediated transport of drugs and their metabolites has recently been recognized as an important issue in pharmaceutical research. There is a wealth of information that suggests that transporters are responsible both for the uptake and efflux of drugs and other xenobiotics, and may be key determinants of the disposition of a drug [91,92]. Transporter proteins are divided into two categories (1) the adenosine triphosphate (ATP) binding cassette (ABC) transporter superfamily and (2) the solute carrier (SLC) family of proteins. 

Nishimura, M., and S. Naito, 2008. Ussue-speeifie mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab. Phaimacokinet. 23,22-44. 

ABC, ATP-binding cassette transporter superfamily ASBT, apical sodium-dependent bile salt transporter BCRP, breast cancer resistance protein BSEP, bile salt export pump MDRl, multidrug resistance MRR multidrug resistance-related protein NTCP, sodium taurocholate cotransporting polypeptide OAT, organic anion transporter OCT, organic cation transporter SLC, solute-linked carrier transporter family SLCO, solute-linked carrier organic anion transporter family. 

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