Oligopeptide transporter

Oligopeptide transporter (Solute carrier family 15, member 1 (SLC15A1))... 

Transport of L-valine-acyclovir via the oligopeptide transporter in the human intestinal cell line, Caco-2., J. Pharmacol. Exp. Ther. 1998, 286, 1166-1170... 

Brodin, S. Frokjaer, M. Taub, and B. Steffansen. Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepTl in the human intestinal Caco-2 cell line.,... 

Mrsny, R. J., Oligopeptide transporters as putative therapeutic targets for cancer cells, Pharm. Res. 1998, 35, 816-818. 

Hidalgo, I. J., Bhatnagar, P., Lee, C.-P., Miller, J., Cucullino, G., Smith, P. L., Structural requirements for interaction with the oligopeptide transporter in Caco-2 cells, Pharm. 

Frokjaer, S., Taub, M., Lennernas, H., Stability, metabolism and transport of D-ASP(OBZL) - a model prodrug with affinity for the oligopeptide transporter, Eur. J. 

Adibi, S. A., The oligopeptide transporter (Pept-1) in human intestine biology and function, Gastroenterology 1997, 3 33, 332—340. 

Thamotharan, M., Bawani, S. Z., Zhou, X., Adibi, S. A., Hormonal regulation of oligopeptide transporter pept-1 in a human intestinal cell line, Am. J. Physiol. 1999, 276, C821-C826. 

Shen, H., et al. Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein... 

Fei, Y. J., V. Ganapathy, and F. H. Leibach. Molecular and structural features of the proton-coupled oligopeptide transporter superfamily. Prog. Nucleic Acid. Res. Mol. Biol. 1998, 58, 239-261. 

Botka, C. W., et al. Human proton/ oligopeptide transporter (POT) genes identification of putative human genes using bioinformatics. AAPS PharmSci. 2000, 2, E16. 

Fei, Y. J., et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 1994, 368, 563-566. 

Tamai, I., et al. The predominant contribution of oligopeptide transporter PepTl to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J. Pharm. Pharmacol. 

Hsu, C.-P., et al. Overexpression of human intestinal oligopeptide transporter in mammalian cells via adenoviral transduction. Pharm. Res. 

Chu, X. Y., et al. Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter. J. Pharmacol. Exp. Ther. 2001, 299, 575-582. 

Friedrichsen, G. M., etal. Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells. Pur. J. Pharm. Sci. 2002, 26, 1-13. 

B., Frokjaer, S., Influence of oligopeptide transporter binding affinity upon uptake and transport of D-Asp(OBzl)-Ala and Asp(OBzl)-Sar in filter grown Caco-2 monolayers, Int. J. Pharm. 1997, 156, 219-228. 

Steffansen, B., Model prodrugs for the intestinal oligopeptide transporter model drug release in aqueous solution and in various biological media, J. Controlled Release, 2001, 73, 21-30. 

S., Steffansen, B., Prodrugs of purine and pyrimidine analogues for oligopeptide transporter, AAPS Pharm. Sci. 2001, 3 suppl. 

Meredith D and Boyd CA (1995) Oligopeptide Transport by Epithelial Cells. J MembrBiol 145 pp 1-12. 

B. S. Anand and A. K. Mitra. Mechanism of corneal permeation of L-valyl ester of acyclovir targeting the oligopeptide transporter on the rabbit cornea. Pharm Res 19 1194-1202 (2002)... 

Peptide and protein drugs must be transported without metabolic degradation to the systemic circulation in order to exhibit or exert their pharmacological action. Although active transport of linear peptides and oligopeptides by intestinal oligopeptide transporters has been reported, overall intestinal absorption of peptides is very poor because of metabolic degradation by peptidases. " ... 

King, N.D. O Brian, M.R. Evidence for direct interaction between enzyme INtr and aspartokinase to regulate bacterial oligopeptide transport. J. Biol. Chem., 276, 21311-21316 (2001)... 

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