Software QUEST

To overcome possible errors in the derived parameters when fitting NMR spectra of powdered samples with large quadrupolar interactions, Perras et al. developed and implemented an exact treatment of the quadrupolar and Zeeman interactions for stationary powdered samples [9]. The software, QUEST (QUadrupolar Exact SofTware), is freely available and produces spectral simulations in a fraction of a second on a modem computer [10]. The importance of this exact treatment was demonstrated in a SSNMR study of a series of organic compounds featuring covalent... 

Liquid chromatography is now a mature technique. Instruments are reliable and increasingly computer assisted. Column-to-column reproducibility is ensured by most manufacturers. The quest for the universal detector is about to end with the advent of a sophisticated and miniaturized MS detector. Development of a method can be achieved in a rather short period with available software. The emphasis is on validation more than on how to handle it. Capillary columns are sure to improve, and the trend will be toward many parallel analyses. 

At Quest, we use spontaneous EEG to measure electrical activity of the brain from the surface of the scalp. A widely available technique, this is also extremely resource-intensive a typical clinical session may take several hours to complete, including the preparation of the subject, the EEG experiment and collation of the resultant data. The vast amounts of data recorded take time to digitize, summarize and analyse. Rapid software enhancements constantly improve this process, making it more accessible to a larger number of research groups. 

F.A. Perras, C.M. Widdifield, D.L. Bryce, QUEST— QUadrupolarExact SofTware a fest graphical program for the exact simulation of NMR and NQR spectra for quadrupolar nuclei. Solid State Nucl. Magn. Reson. 45—46 (2012) 36 4. 

CSH QUEST Protein Database Center (2D REF52 rat, mouse embryo, yeast. Quest software)... 

Acknowledgments This research was supported by the National IT Industry Promotion Agency (NIPA) under the program of Software Engineering Technologies Development. The authors would like to express thanks to research staff at the Korea Artificial Organ Center. Mr Chi-bum Aim provided extraordinary support in our quest to understand the H-VAD system and validate its software safety. 

Tel. 44-1223-336408, fax 44-1223-336033, e-mail software crystallography.chemistry.cambridge.ac.uk Database with more than 130,000 X-ray structures of low-molecular-weight organic and organometailic compounds. QUEST for data retrieval using con-... 

Further development in this field will be governed by questions related to the yet unsolved fundamental and technical issues as well as the quest for more user-fnendly implementations of the techniques. Although the STM and NC-AFM technologies already allow operation at most advanced levels, still most technical implementations operate at technical rather than physical hmits. This specifically applies to the NC-AFM where improvements in the detection optics and electronics, frequency demodulation, control software, and electronics still have to be made [275]. An equally important technical issue is the further development and widespread implementation of advanced atom tracking and feed-forward... 

---