Soft tissue infections necrotizing

Kahn LH, Styrt BA. Necrotizing soft tissue infections reported with nonsteroidal antiinflammatory drugs. Ann Pharmacother 1997 31(9) 1034-9. 

In another study carried out in fasted ponies, the oral administration of a flunixin meglumine paste (l.lmg/kg) resulted in peak plasma concentrations >2 jLg/ml less than 1 h after administration (Welsh et al 1992). In ponies with free access to hay, the peak plasma concentration decreased to approximately 1.3 j,g/ml and the peak concentration was not reached until 7.6 h after administration (Welsh et al 1992). Nevertheless, the mean area under the plasma concentration-time curve (AUC) was not significantly different whether the ponies had been fasted or fed. The parenteral preparation of flunixin meglumine can be administered i.m. however, necrotizing soft-tissue infections have been reported following i.m. administration (Kahn Styrt 1997) and so aseptic preparation of the injection site is advisable. 

Kahn L H, Styrt B A 1997 Necrotizing soft tissue infections reported with nonsteroidal anti-inflammatory drugs. Annals of Pharmacotherapy 31 1034-1039 Karcher L R Dill S G, Anderson W I et al 1990 Right dorsal colitis. Journal of Veterinary Internal Medicine 4 247-253... 

Urschel JD. Necrotizing soft tissue infections. Postgrad Med J 1999 75 645-649. 

C.L. Zanetti, Necrotizing soft tissue infection and adjunctive hyperbaric oxygen. Chest, 92 670... 

Another important necrotizing skin and soft tissue infection is clostridial myonecrosis (gas gangrene). Clostridial myonecrosis can develop spontaneously but most often occurs after trauma. Clostridium perfringens is the most common causative pathogen. 

Necrotizing fasciitis A severe soft-tissue infection involving the... 

Deeper bacterial infections of the skin include folliculitis, erysipelas, cellulitis, and necrotizing fasciitis. Since streptococcal and staphylococcal species also are the most common causes of deep cutaneous infections, penicilUns (especially ji-lactarruise-resistant ji-lactams), and cephalosporins are the systemic antibiotics used most frequently in their treatment (see Chapter 44). A growing concern is the increased incidence of skin and soft tissue infections with hospital- and community-acquired methicillin-resistant S. aureus (MRSA) and drug-resistant pneumococci. Infection with community-acquired MRSA often is susceptible to trimethoprim—sulfamethoxazole. 

Fish-handler s disease Rosenbach s erysipeloid with purplish red indurated plaque with central clearing Typically self limited Necrotizing myositis or soft tissue infection... 

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