Sodium 2-pyridinethiol-1-oxide

N-Hydroxythiopyridone is purchased from the Olin Corp. as an aqueous 40% solution of sodium 2-pyridinethiol-1-oxide (sodium omadine). Sodium omadine (1 L) is diluted with water (H2O, 600 mL) and the solution cooled to 0°C. Hydrochloric acid (350 mL) is added dropwise over a 20-min interval with continuous stirring and cooling for a further 20 min. The resulting suspension containing N-hydroxythio-pyridone is filtered and the solid is washed with H2O (2 L). The N-hydroxythiopyridone is dried over sodium hydroxide or potassium hydroxide under reduced pressure and... 

Sodium metaperiodate Periodic acid, sodium salt (7790-28-5), 75, 108 Sodium nitrite Nitrous acid, sodium salt (7632-00-0), 75, 37 77, 237 Sodium omadine See Sodium 2-pyridinethiol-1 -oxide, 75, 125 Sodium 2-pyridinethiol-1-oxide (sodium omadine), 75, 125 Sodium sulfide, 76, 95... 

Sodium 2-pyridinethiol-1-oxide Sodium 2-pyridinediiol-N-oxide Sodium -pyridylthio)-N-oxide. See Sodium p thione... 

CAS 3811-73-2 EINECS/ELINCS 223-296-5 Synonyms (1 -Hydroxy-2-pyridinethione), sodium salt 2-Meicaptopyridine-N-oxide, sodium salt 2-Pyridinethiol-1-oxide, sodium salt Sodium 2-pyridinethiol-1-oxide Sodium 2-pyridinethiol-N-oxide Sodium (2-pyridylthio)-N-oxide Classification Organic compd. 

Sodium 2-pyridinethiol-1-oxide - 226 Sodium pyrithione 223 Sodium salts of chlorophenols - 58 Sulfur-116,121... 

A number of new procedures have been developed for the oxidation of sulfur-linked substituents on the pyridine ring at sulfur. 2- and 4-Pyridinethiols may be oxidized to the corresponding sulfonyl chloride at low temperature using sodium hypochlorite in a mixture of dichloromethane and 1M aqueous HC1 <2006JOC1080>. Treatment of the crude solution of sulfonyl chloride in dichloromethane with benzylamine results in rapid conversion to the sulfonamide. Carrying out the oxidation in the presence of KHF2 and tetrabutylammonium sulfate results in conversion to the sulfonyl fluoride. For example, 2-pyridinethiol is converted to the sulfonamide in 98% yield and the sulfonyl fluoride in 70% yield using this procedure (Scheme 27). In the same manner, 4-pyridinethiol is converted to the sulfonyl chloride in 39% yield and 2-quinolinethiol is converted to the sulfonyl chloride and sulfonyl fluoride in 80% and 49% yield, respectively. 

Sodium 4-pyridinesulfonate has been obtained from the oxidation of 4-pyridinethiol with hydrogen peroxide in sodium hydroxide solution, and from the reaction of 4-chloropyridine with aqueous sodium sulfite. The salt has been converted to the free acid by treatment with a cation-exchange resin - or with sulfuric acid. ... 

Pyridinethiol-1-oxide, sodium salt. See Sodium pyrithione... 

Sodium benzoate Sodium pentachlorophenol Sodium 2-pyridinethiol-l-oxide Sodium sorbate Sodium dehydroacetate l,2-Dibenzisothiazolin-3-one... 

Synonyms sodium 2-pyridinethiol-i-oxide sodium pyrithione 2-mercaptopyridine N-oxide, sodium salt N-hydroxy-2-pyridi-nethione, sodium salt 2-pyridinethiol-i-oxide, sodium salt mercaptopyridine N-oxide sodium salt... 

In some related work, the same authors reported on the preparation of C-10 alkoxy derivatives via a 3-methylenecepham intermediate (Ochiai etai, 1972c). First, 2-[4-carboxy-7-(thiophene-2-acetamido)-3-cephem-3-yl-methylthio]-pyridineN-oxide (10) was prepared by displacement of the C-10 acetoxy group in cephalothin sodium salt by 2-pyridinethiol N-... 

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