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Sodium channels, pyrethroid insecticide

The compounds featured in Table 1.1 are considered briefly here. Pyrethrins are lipophilic esters that occur in Chrysanthemum spp. Extracts of flower heads of Chrysanthemum spp. contain six different pyrethrins and have been used for insect control (Chapter 12). Pyrethrins act upon sodium channels in a manner similar to p,p -DDT. The highly successful synthetic pyrethroid insecticides were modeled on natural pyrethrins. [Pg.4]

In some resistant strains, both types of resistance mechanism have been shown to operate against the same insecticide. Thus, the PEG87 strain of the tobacco bud worm (Heliothis virescens) is resistant to pyrethroids on account of both a highly active form of cytochrome P450 and an insensitive form of the sodium channel (Table 4.3 and McCaffery 1998). [Pg.95]

Pyrethroid insecticides are generally recognized as potent neurotoxicants that interfere with nerve membrane function by interaction with the sodium channel (Elliott and Janes 1978 Vijverberg et al. 1982 Gilbert et al. 1989 Haya 1989). Synthetic pyrethroids are more toxic against insect pests, up to 10 times more potent in some cases, than other insecticides now in general use (Bradbury... [Pg.1091]

The sodium channel in the nerve membrane is the major target site for all synthetic pyrethroid insecticides (and many other neurotoxicants)... [Pg.1100]

Smith TJ, Soderlund DM (1998) Action of the pyrethroid insecticide cypermethrin on rat brain Ha sodium channels expressed in Xenopus oocytes. Neurotoxicology 19 823-832... [Pg.69]

Choi JS, Soderlund DM (2006) Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes. Toxicol Appl Pharmacol 211 233-244... [Pg.69]

Tan J, Soderlund DM (2009) Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. Neurotoxicology... [Pg.69]

Tan J, Soderlund DM (2010) Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Nav 1.6 sodium channels. Toxicol Appl Pharmacol 247 229—237... [Pg.70]

Bloomquist JR, Soderlund DM (1988) Pyrethroid insecticides and DDT modify alkaloid-dependent sodium channel activation and its enhancement by sea anemone toxin. Mol Pharmacol 33 543-550... [Pg.70]

Brown GB, Gaupp JE, Olsen RW (1988) Pyrethroid insecticides stereospecific allosteric interaction with the batrachotoxinin-a benzoate binding site of mammalian voltage-sensitive sodium channels. Mol Pharmacol 34 54-59... [Pg.70]

Lombet A, Mourre C, Lazdunski M (1988) Interaction of insecticides of the pyrethroid family with specific binding sites on the voltage-dependent sodium channel from mammalian brain. Brain Res 459 44—53... [Pg.70]

The mechanism of insecticidal action has been attributed to blocking of the sodium channel in target cell membranes and consequent blocking of ion transport [124]. Following these observations a considerable effort was developed for the preparation of synthetic pyrethroids as commercial insecticides. [Pg.21]

Pyrethroid insecticides. The natural pyrethrins, which act on the voltage-gated sodium channel, are highly potent insecticides obtained from flowers of the chrysanthemum plant. Though the pyrethrins are highly active insecticides, they are not stable enough for commercial use. However, a number of structural modifications of the early pyrethrin molecule resulted in a wide range of stable commercially useful pyrethroid insectides. [Pg.131]

Batrachotoxin at present remains an important, indeed often essential, tool for mechanistic studies of the function of voltage-dependent sodium channels and for the investigation of the role of depolarization and/or influx of sodium ions on physiological functions. Batrachotoxin has been particularly useful in the study of the function of sodium channels, purified and reconstituted into artificial lipid bilayers. A summary and overview of the extensive studies with batrachotoxin appeared in 1986 (5). Since that time more than 100 articles dealing with the activity of batrachotoxin and/ or the radioligand batrachotoxinin A 20a-[ H]benzoate have appeared, and it is beyond the scope of the present review to summarize this extensive recent literature. A few selected developments are as follows allosteric enhancement of the action of batrachotoxins by pyrethroid insecticides... [Pg.191]

It is believed that DDT (and related analogs) and pyrethroid insecticides bind to sodium channels (Figure 7.6), which causes a delay in sodium channel closing, i.e., prolonged... [Pg.118]

Because of the intimate involvement of sodium channels in pyrethroid insecticide resistance (see below), partial cDNA clones of para-orthologs were isolated from other in-... [Pg.168]

Differential Sensitivity of Sodium Channel Isoforms to Pyrethroid Insecticides... [Pg.171]

See other pages where Sodium channels, pyrethroid insecticide is mentioned: [Pg.301]    [Pg.5]    [Pg.10]    [Pg.59]    [Pg.95]    [Pg.99]    [Pg.157]    [Pg.238]    [Pg.296]    [Pg.298]    [Pg.1126]    [Pg.50]    [Pg.139]    [Pg.1126]    [Pg.56]    [Pg.301]    [Pg.141]    [Pg.120]    [Pg.208]    [Pg.215]    [Pg.167]    [Pg.168]    [Pg.171]    [Pg.193]    [Pg.963]    [Pg.217]    [Pg.258]    [Pg.271]    [Pg.306]    [Pg.90]   


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