Sodium bicarbonate Lithium compounds

Method for producing a-nucleants in-situ in a molten polypropylene by reacting particles of an insoluble non-nucleating dispersed phase metal salt or oxide with a soluble organic compound is disclosed. The reactive product of these two components is an a-nucleant which coats the dispersed phase particles. The dispersed particle comprises sodium carbonate, sodium bicarbonate, lithium carbonate, or their combination. The second soluble chemical component comprises benzoic acid. ... 

The key intermediate 124 was prepared starting with tryptophyl bromide alkylation of 3-acetylpyridine, to give 128 in 95% yield (Fig. 37) [87]. Reduction of 128 with sodium dithionite under buffered (sodium bicarbonate) conditions lead to dihydropyridine 129, which could be cyclized to 130 upon treatment with methanolic HC1. Alternatively, 128 could be converted directly to 130 by sodium dithionite if the sodium bicarbonate was omitted. Oxidation with palladium on carbon produced pyridinium salt 131, which could then be reduced to 124 (as a mixture of isomers) upon reaction with sodium boro-hydride. Alternatively, direct reduction of 128 with sodium borohydride gave a mixture of compounds, from which cyclized derivative 132 could be isolated in 30% yield after column chromatography [88]. Reduction of 132 with lithium tri-f-butoxyaluminum hydride then gave 124 (once again as a mixture of isomers) in 90% yield. 

Thebaine has been converted into the 14-substituted compound (136 R = SCN) by treatment with (SCN)2, and this gives the ketal (136 R = OMe) when treated with methanol. The initial product (136 R = SCN) is hydrolysed to the codeinone by sodium bicarbonate, and reduction of this with lithium aluminium hydride gives 14-mercaptocodeine (137), which can be demethylated to 14-mercaptomorphine by boron trifluoride.166... 

Aqueous alkali or basic medium is generally used as the catalyst for the preparation of epoxy resins. Useful base compounds include alkali and alkaline earth metal bicarbonates, carbonates, hydroxides or hydrides or alkoxides. A few of such compounds are sodium carbonate (Na2C03), potassium carbonate (K2CO3), lithium carbonate (Li2C03), calcium carbonate (CaC03), sodium hydroxide (NaOH), potassium hydroxide (KOH), lithium hydroxide (LiOH), calcium hydroxide (Cao.sOH), sodium bicarbonate (NaHC03), potassium bicarbonate (KHCO3), lithium bicarbonate... 

Like their aryl and alkenyl counterparts, alkynylboronic adds can be made by displacement of magnesium or lithium acetylides with borate esters. For example, Mat-teson and Peacock have described the preparation of dibutyl acetyleneboronate from ethynylmagnesium bromide and trimethyl borate [294]. The C-B hnkage is stable in neutral or acidic hydrolytic solvents but readily hydrolyzes in basic media such as aqueous sodium bicarbonate. Brown and co-workers eventually applied their organo-lithium route to boronic esters to the particular case of alkynylboronic esters, and in this way provided a fairly general access to this class of compounds [295]. 

Under the protection of nitrogen, the compound 3.6 (800 mg, 2.4 mmol) was dissolved in tetrahydrofuran (20 mL), and then, lithium aluminum hydride (365 mg, 9.6 mmol) was added at 0 °C. The reaction was stirred at room temperature for 24 h. TLC showed that the reaction was completed. The water (4 mL) was slowly added to quench the reaction at 0 °C. The reaction system was filtered and diluted with ethyl acetate (200 mL), washed with saturated sodium bicarbonate (3 X 50 mL), and the aqueous phase was extracted with ethyl acetate (300 mL) and washed with saturated brine (100 mL). The combined organic phases were dried over Na2S04 and filtered, and the solvent was removed by rotary evaporator the crude product was purified by column chromatography using silica gel (EtOAc/hexane = 1 10) to give a total yield of 84 % of the compound 3.5a (89 mg) and 3.5b (530 mg). 

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