SMART identification

Ponting CP, Schultz J, Milpetz F, Bork P. SMART identification and annotation of domains from signalling and extracellular protein sequences. Nucleic Acids Res 1999 27[l] 229-232. 

As main conclusion we establish the requirement for a smart identification and testing of open source software components before integrating them during the software development process, in order to produce reliable software. Also, we conclude with the reqitire-ment for a revised definition of the software reUabiUty in order to cover software security aspects. 

L.E. Smart, Separation, Purification and Identification, The Royal Society of Chemistry, London, 2002 (in paperback and CD-ROM). ISBN 0854046852. 

Schultz, J., et al., SMART, a simple modular architecture research tool identification of signaling domains. Proc Natl Acad Sci USA, 1998, 95(11), 5857-64. 

UV curable flexo ink for RFID antennas Radio frequency identification (RFID) devices and contactless smart cards are capable of uniquely identifying an individual or object when they are interrogated by an external radio frequency signal. Recently, a process of printing with the use of UV curable conductive flexo inks has been introduced. The inks are based on polyfunctional acrylates with silver flakes added for the electrical conductivity. The advantages of these inks are ... 

As Protagen AG is a specialist in applied protein science, we have designed a concept for target discovery and lead identification, the small molecule adaptation on research targets (SMART) approach (Figure 10.1). The concept is based on common knowledge and on the hypothesis that every drug sold in the market... 

The diverse and different pharmacological effects on several central biosynthetic pathways and signaling cascades that are reported for Leflunomide recommended this small molecule drug for employment of the SMART approach for the identification of alternative targets and finally, lead stmcture identification. 

As discussed above, not all of the proteins identified by mode-of-action studies employing the SMART approach are suitable drug targets. However, the identification of enzymes of the glycolytic complex by affinity chromatography and their validation by BIAcore analysis finally led to the working hypothesis that Leflimo-... 

Usnally a nncleic acid probe that emits a signal only when bound to a specific target. An example is a molecular beacon. See Stohr, K., Hafner, B., Nolle., O. et al.. Species-specific identification of mycobacterial 16S rRNA PCR amplicons nsing smart probes. Anal. Chem. 77, 7195-7203, 2005. There are other examples of smart probes inclnding proteins (Wunder, A., Tung, C.-H., Mtiller-Ladner, U., Weissleder, R., and Mahmood, U., In vivo imaging of protease activity in arthritis, a novel approach for monitoring treatment response, Arthritis Rheumatism 50, 2459-2465, 2004) and chiral compounds (Tsukube, H. and Shinoda, S., Lanthanide complexes as smart... 

Identification of the active sites of the MgO surface is of crucial importance for the understanding of the reaction mechanisms and the properties of MgO(lll) nanosheets. Methanol is a smart molecular probe that can provide fundamental information about the number and nature of active surface sites [238]. Methanol... 

Data-dependent acqnisition (DDA) is a mode of operation, where the MS experiment performed in a particular scan is based on the data acqnired in a previons scan. In a simple form, a DDA experiment switches the instrument from full-scan MS acquisition to full-scan product-ion MS-MS when the total-ion intensity or a selected-ion intensity exceeds a preset threshold. This avoids the need to perform two consecutive injections for the identification of unknowns in a mixture first to obtain the m/z values for the intact protonated molecules of the unknowns, and second to acquire the product-ion MS-MS spectra of these unknowns in a time-scheduled procedure, switching between various preselected precursor ions as a function of the chromatographic retention time. The DDA was promoted by Thermo Finnigan upon the introduction of the API-ion trap combinations [44-46]. Similar procedures are available for other commercial ion-trap systems, as well as for triple-quadrupoles, e.g.. Information Dependent Acquisition (IDA) from Applied Biosystems MDS Sciex, Data-directed Analysis (DDA) from Waters, and Smart Select from Bruker. 

Rapid diagnostic SMART Tickets are currently available for identification of biological agents Anthrax and Plague. 

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