Vascular prosthesis small-diameter

Lyman DJ, Albo D, Jackson R Jr. and Knntson K, Development of small diameter vascular prostheses Trans. Am. Soc. Artif. Intern. Organs, 1977 23 253-261. Madras P, Ward C, Johnson W and Singh P, Anastomotic hyperplasia Surgery, 1981 90(5) 992-993. 

Malone JM, Brendel K, Duhamel R and Reinert RL. Detergent extracted small diameter vascular prostheses. /. Vase. Surg. 1 181-191,1984. 

These observations indicated that MPC polymer in SPU can improve the anti-thrombogenicity of SPU, and the SPU/MPC polymer blend has potential for use in the preparation of small-diameter vascular prostheses. 

Small-diameter vascular prostheses with incorporated matrices can be absorbed into a growing anastomotic neointima. It was pointed out that a gelatin-heparin complex when adequately cross-linked, could simultaneously function as a temporary antithrombogenic surface and as an exceptional substructure for an anastomotic... 

Vascular grafts Nowadays, researchers are more interested in developing acceptable small-diameter vascular prostheses. The authors have designed small-diameter vascular prostheses, which include matrices with the ability to absorb growing anastomotic neointima. This property points out that a gelatin heparin complex, when adequately crosslinked, can simultaneously ftmction as a temporary anti-thrombogenic surface and as an excellent substructure for an anastomotic neointima... 

Small diameter vascular prostheses with incorporated bioabsorbable matrices. A preliminary study. ASAIO JouitmI, 39,... 

Since the current prosthesis materials are thrombogenic, our approach to solving the small diameter vascular prostheses problem was to develop a blood compatible pol3nner. There appears to be ample evidence from our studies and those of others to support the contention that protein adsorption is the first event occurring as blood comes in contact with a pol3nner surface vivo (1-10). 

At the time of this writing, the compliant copolyurethane vascular prostheses are still patent at 15 months implantation. One prosthesis removed at this time showed minimal hypertrophy. Thus, to achieve success in small diameter vascular prostheses, one must balance the surface chemical and physical properties of the material for blood compatibility and the mechanical properties for matching the compliancy of the natural vessel. 

In summary, our studies have shown that it is necessary to incorporate the proper chemical, physical and mechanical properties into a polymer implant if a workable small diameter vascular prosthesis is to be achieved. To do this, one must couple basic research on the polymer surface using a variety of techniques with the more applied implant studies where the variables of mechanical properties show their influence. 

Yoneyama T, Ishihara K, Nakabayashi N, Ito M, Mishima Y. Short-term in vivo evaluation of small-diameter vascular prosthesis composed of segmented poly(etherure-thane)/2-methacryloyloxyethyl phosphorylcholine polymer blend. J Biomed Mater Res Appl Biomater 1998 43(1) 15-20. 

Yoneyama T, Ito M, Sugihara K, Ishihara K, Nakabayashi N. Small diameter vascular prosthesis with a nonthrombogenic phospholipid polymer surface preliminary study of a new concept for functioning in the absence of pseudo- or neointima formation. Artif Organs 2000 24(l) 23-8. 

T. Okoshi, G. Soldani, M. Goddard, P.M. Galletti, Very small diameter polyurethane vascular prosthesis with rapid endotheliahzation... 

Figure 11.12 In vivo evaluation of small-diameter polyester vascular prosthesis coated with SPU and SPU/PMEH polymer alloy.

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