2-Methacryloyloxyethyl phosphorylcholine polymer

S., Hasebe, T., and Hotta, A. (2014) Preparation and characterization of 2-methacryloyloxyethyl phosphorylcholine polymer nanofibers prepared via electrospinning for biomedical materials. J. Appl. Polym. Sci, 131, 40606... 

Konno T, Kurita K, Iwasaki Y, Nakabayashi N, Ishihara K (2001) Preparation of nanoparticles composed with bioinspired 2-methacryloyloxyethyl phosphorylcholine polymer. Biomaterials 22 1883-1889... 

Ishihara K, Iwasaki Y. Biocompatible elastomers composed of segmented polyurethane and 2-methacryloyloxyethyl phosphorylcholine polymer. Polym Adv Technol 2000 ll(8-12) 626-38. 

Ishihara K, Fujita H, Yoneyama T, Iwasaki Y. Antithrombogenic polymer alloy composed of 2-methacryloyloxyethyl phosphorylcholine polymer and segmented polyurethane. J Biomater Sci Polym Ed 2000 ll(ll) 1183-95. 

Yoneyama T, Ishihara K, Nakabayashi N, Ito M, Mishima Y. Short-term in vivo evaluation of small-diameter vascular prosthesis composed of segmented poly(etherure-thane)/2-methacryloyloxyethyl phosphorylcholine polymer blend. J Biomed Mater Res Appl Biomater 1998 43(1) 15-20. 

Ishihara K, Fukazawa K. 2-methacryloyloxyethyl phosphorylcholine polymer. In Monge S, David G, editors. Phosphorus-based polymers from synthesis to applications. (Cambridge, UK) RSC Publishing 2014. pp. 68-96. [Chapter 5]. 

Many kinds of nonbiodegradable vinyl-type hydrophilic polymers were also used in combination with aliphatic polyesters to prepare amphiphilic block copolymers. Two typical examples of the vinyl-polymers used are poly(/V-isopropylacrylamide) (PNIPAAm) [149-152] and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) [153]. PNIPAAm is well known as a temperature-responsive polymer and has been used in biomedicine to provide smart materials. Temperature-responsive nanoparticles or polymer micelles could be prepared using PNIPAAm-6-PLA block copolymers [149-152]. PMPC is also a well-known biocompatible polymer that suppresses protein adsorption and platelet adhesion, and has been used as the hydrophilic outer shell of polymer micelles consisting of a block copolymer of PMPC -co-PLA [153]. Many other vinyl-type polymers used for PLA-based amphiphilic block copolymers were also introduced in a recent review [16]. 

Tumoko and coworkers [485] showed that polymers based on acrylamide, methyl propane sulfonic acid and butyl methacrylate in conjunction with poly(2 methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate) are capable of suppressing platelet adherence. Similar results [486] were found on poly(gamma benzyl 1 glutamate-co-leucine) neutralized with sodium. 

Zhu, A., Zhang, M., and Shen, J. (2002). Cell adhesion behavior of chitosan surface modified by bonding 2-methacryloyloxyethyl phosphorylcholine,/. Biomater. Sci. Polym. Ed., 13(5), 501-510. 

The surface of PEEK can be protected by a hydrophilic high density nanometer-scaled layer on the surface by the photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine. Photo-initiators are not needed, the reaction is a self-initiated surface graft polymerization. Actually, the diphenylketone moiety in the PEK polymer backbone acts as a photo-initiator similar to benzophenone. Since the photoinduced polymerization occurs only at... 

Next, in order to demonstrate the efficacy of this cell surface engineering approach, cell microarrays were prepared using a micropattemed poly(2-methacryloyloxyethyl phosphorylcholine [MPC]) (PMPC) polymer brush surface as the substrate. PMPC brushes were prepared on a silicon (Si) wafer via surface-initiated atom transfer radical polymerization, as previously described elsewhere [35]. Selective decomposition of the initiators immobilized on the Si wafer using UV light irradiation resulted in micropatterning of the... 

Jin Z, Feng W, Zhu S, Sheardown H, Brash JL. Protein-resistant materials via surface-initiated atom transfer radical polymerization of 2-methacryloyloxyethyl phosphorylcholine. J Biomater Sci Polym Ed 2010 21(10) 1331. ... 

Lee I, Kobayashi K, Sun HY, Takatani S, Zhong LG. Biomembrane mimetic polymer poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) at the interface of polyurethane surfaces. J Biomed Mater Res A 2007 82(2) 316-22. 

A biodegradable poly (ester urethane)urea (PEUU) was blended with a phospholipid polymer of poly(methacryloyloxyethyl phosphorylcholine-co-methacryloyloxyethyl butyl urethane) (PMBU) (molar ratio=70/30), in HFIP solvent, and then coelectfospun... 

Feng, W., Brash, J., Zhu, S. (2004). Atom-transfer radical grafting polymerization of 2-methacryloyloxyethyl phosphorylcholine from silicon wafer surfaces. Journal of Polymer Science Part A Polymer Chemistry, 42, 2931-2942. 

Hirota, K., Murakami, K., Nemoto, K., Miyake, Y. (2005). Coating of a surface with 2-methacryloyloxyethyl phosphorylcholine (MPC) co-polymer significantly reduces retention of human pathogenic microorganisms. FEMS Microbiology Letters, 248, 37-45. 

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