Small cell lung carcinoma

Gefitinib (Iressa ) Astra-Zeneca TKI EGFR Metastatic non-small cell lung carcinoma... 

ACTH-secreting non-pituitary tumors (ectopic ACTH syndrome)—15% of cases of endogenous Cushing s syndrome usually from small cell lung carcinoma, bronchial carcinoids, pheochromocytoma, or thymus, pancreatic, ovarian, or thyroid tumor. The tumor is usually disseminated (difficult to localize). 

Identify the chemotherapeutic regimens of choice for limited and extensive small cell lung carcinoma, as well as local, locally advanced, and advanced non-small cell lung carcinoma. 

Lambert-Eaton syndrome is an antibody-mediated neuromuscular junction disorder. This disorder, which is most frequently encountered in patients with small-cell lung carcinoma, is characterized clinically by weakness and hyporeflexia. The impaired release of acetylcholine vesicles from presynaptic terminals at neuromuscular junctions that causes the weakness is a consequence of autoantibodies against small cell carcinoma epitopes that cross-react with and downregulate the expression of motor nerve terminal Ca2+ channels [39]. (See in Ch. 43.)... 

Lee, L. and Bebb, G., A case of Bowen s disease and small-cell lung carcinoma Longterm consequences of chronic arsenic exposure in Chinese traditional medicine, Environ. Health Perspect., 113, 207, 2005. 

Wesley UV, Tiwari S, Houghton AN (2004) Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells. Int J Cancer 109(6) 855—866. 

Tanaka, M., N. Inase, S. Miyake, and Y. Yoshizawa. 2001. Neuron specific enolase promoter for suicide gene therapy in small cell lung carcinoma. Anticancer Res 21(lA) 291-4. 

Prins, J., E. G. De Vries, and N. H. Mulder. 1993. The myc family of oncogenes and their presence and importance in small-cell lung carcinoma and other tumour types. Anticancer Res 13(5A) 1373-85. 

Combination studies with PKCa antisense and standard chemotherapeutic agents (cis-platin, mitomycin-C, vinblastine, estracyt and adriamycin) in nude mice that had been transplanted with a variety of human tumors (breast, prostate, large cell lung and small cell lung carcinomas, and melanomas) were found to be additive or superadditive (Geiger et al, 1998). 

PKCi was amplified in established head and neck cancer cell lines, snggested that PKCi may fimction as an oncogene in head and neck cancer, similar to its role in non-small cell lung carcinoma. 

Puyol M, Martin A, Dubus P et al (2010) A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18 63-73... 

Koukourakis MI, B ahlitzanakis N, Froudarakis M, et al. Concurrentconventionally fractionated radiotherapy and weekly docetaxel in the treatment of stage IIIB non-small cell lung carcinoma. BrJ Cancer 1999 80 1792-1796. 

Levitan N, Dowlati A, Shina D, et al. Multi-institutional phase ITU trial of paclitaxel, cisplatin, and etoposide with concurrent radiation for limited-stage small-cell lung carcinoma. J Clin Oncol 2000 18(5) 1102-1109. 

Gy in favorable patients with radiation oncology group stage III non small cell lung carcinoma Report of Radiation Therapy Oncology Group 83-11. J Clin Oncol 1990 8 1543-1555. 

Bonner JA, McGinnis WL, Stella PJ, et al. The possible advantage of hyperfractionated thoracic radiotherapy in the treatment of locally advanced non-small cell lung carcinoma Results of the North Central Cancer Treatment Study Group Phase III trial. Cancer 1998 82 1037-1048. 

Strauss GM, Langer MP, Elias AD, et al. Multimodality treatment of stage IIIA non-small cell lung carcinoma A critical review of the literature and strategies for future research. J Clin Oncol 1992 10 829-838. 

Choi N, Carey R. Importance of radiation dose in achieving improved loco-regional tumor control in limited stage small-cell lung carcinoma an update. Int J Radiat Oncol Biol Phys 1989 17 307-310. 

Lebeau B, Urban T, Brechot JM, et al. A randomized clinical trial comparing concurrent and alternated thoracic irradiation for patients with limited small-cell lung carcinoma. Cancer 1999 86 1480-1487. 

Marrogi AJ, Travis WD, Welsh JA, et al. Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res 2000 6 4739 1744. 

---