Sleep disorders treatment with

Melatonin [73-31-4] C 2H N202 (31) has marked effects on circadian rhythm (11). Novel ligands for melatonin receptors such as (32) (12), C2yH2gN202, have affinities in the range of 10 Af, and have potential use as therapeutic agents in the treatment of the sleep disorders associated with jet lag. Such agents may also be usehil in the treatment of seasonal affective disorder (SAD), the depression associated with the winter months. Histamine (see Histamine and histamine antagonists), adenosine (see Nucleic acids), and neuropeptides such as corticotropin-like intermediate lobe peptide (CLIP) and vasoactive intestinal polypeptide (VIP) have also been reported to have sedative—hypnotic activities (7). 

Evaluate the clinical outcomes of treatment by using the UPDRS. In addition, periodically ask patients to record the amount of on and off time they have with and without dyskinesias in a diary. There are a variety of scales that can be used to assess QOL, depression, anxiety, and sleep disorders. Patients with PD cannot be cured but treatment can delay the progression of symptoms and improve QOL. Delaying the patient s admission into a nursing home is a good outcome. 

Different lines of treatment for sleep disorders associated with EDS, such as continuous positive airway pressure or airway surgery, were evaluated using the MSLT. In comparing pre- and posttreatment symptoms, a subject may perceive an improvement of awareness as very substantial, whereas the MSLT may reveal that the vulnerability remains. Hence, objective assessment of the response is offered by the MSLT (16,54). The alerting effect of caffeine has been proven by its ability to increase the sleep latency on the MSLT of normal sleep-deprived subjects (55). 

Valerian is promoted in the United States primarily as a sedative-hypnotic for treatment of insomnia, and as an anxiolytic for restlessness and sleeping disorders associated with anxiety (4,7). 

Esterification of the corresponding quinoline-4-carboxylic acid gave the ester 511 which upon reaction with pyrrolidine in THE gave the amide 512. Its phosphorylation and reaction with 513 in presence of KOBu afforded 514 which is useful in the treatment of anxiety, sleep disorders, panic states, convulsions, muscle disorders (95WOP9514020) and chronic neurodegen-erative diseases (97WOP9700074) (Scheme 87). 

To determine the success of treatment, evaluate whether the treatment plan restored normal sleep patterns, reduced daytime sequelae, and improved quality of life without causing adverse effects. Schedule patients for follow-up within 3 weeks for insomnia and within 3 months for other sleep disorders. Perform a detailed clinical history to determine the patient s perception of treatment progress and symptoms along with medication effectiveness and side effects. 

FIGURE 72-1. Algorithm for treatment of dyssomnias. (BZDRA, benzodiazepine receptor agonist CPAP, continuous positive airway pressure.) (Adapted and reprinted with permission from Jermain DM, Sleep disorders. IntJann M, ed. Pharmacotherapy Self-Assessment Program, 2nd ed. Kansas City, MO, American College of Clinical Pharmacy, 1995 139-154.)... 

In this chapter, we will not attempt to provide an exhaustive description of every sleep disorder. Medication therapy plays a minimal role in the treatment of many sleep disorders. In fact, we contend that medication, apart from being an integral component of a comprehensive multimodal treatment program, is seldom an effective treatment for any sleep problem with the possible exception of acute insomnia due to an identifiable and short-lived stressor. Nevertheless, medications do play a part in the treatment of some sleep disorders. 

Papadimitriou GN, Kerkhofs M, Kempenaers C, et al EEG sleep in patients with generalized anxiety disorder. Psychiatry Res 26 183-190, 1988 Papadimitriou GN, Christodoulou GN, Katsouyanni K, et al Therapy and prevention of affective illness by total sleep deprivation. J Affect Disord 27 107-116, 1993 Papp M, Muscat R, Willner P Additive effects of chronic treatment with antidepressant drugs and intermittent treatment with a dopamine agonist. Eur Neuropsy-chopharmacol 2 121-125, 1992... 

Riemann D, Berger M The effects of total sleep deprivation and subsequent treatment with clomipramine on depressive symptoms and sleep electroencephalography in patients with a major depressive disorder. Acta Psychiatr Scand 81 24-31, 1990... 

Modafinil is a stimulant medication used to improve wakefulness in patients with narcolepsy, obstructive sleep apnea/hypopnea syndrome (as adjunct to standard treatments for the underlying disorder), and shift work sleep disorder. Controlled and open trials provided data on the efficacy and safety of modafinil in patients with narcolepsy (Besset et al. 1996 Billiard et al. 1994 Broughton et al. 1997 Mitler et al. 2000 U.S. Modafinil in Narcolepsy Multicenter Study Group 1998, 2000). Modafinil has a long duration of action and low potential for dependence and may be a reasonable first choice in the treatment of mild to moderate narcolepsy (Silber 2001). There is also considerable interest in the potential use of modafinil in the treatment of ADHD, and studies are in progress. 

The International Classification of Sleep Disorders lists 88 types, with insomnia the most prominent symptom for many of these (17). Chronic insomnia is the most common sleep problem for which patients consult practitioners (18) and usually reflects psychological/ behavioral disturbances ( 19). Differences in treatment recommendations support the distinction between DSM-IV and the International Classification for Sleep Disorders ( 20). The DSM-IV divides primary disorders into two major groups the dyssomnias (in which the predominant disturbance is the amount, quality, or timing of sleep) and the parasomnias (in which the predominant disturbance is an abnormal event occurring during sleep) (7). 

Prescription medications such as pain relievers, central nervous system (CNS) depressants (tranquilizers and sedatives), and stimulants are highly beneficial treatments for a variety of health conditions. Pain relievers enable individuals with chronic pain to lead productive lives tranquilizers can reduce anxiety and help patients with sleep disorders and stimulants help people with attention-deficit hyperactivity disorder (ADHD) focus their attention. Most people who take prescription medications use them responsibly. But when abused—that is, taken by someone other than the patient for whom the medication was prescribed or taken in a manner or dosage other than what was prescribed—prescription medications can produce serious adverse health effects, including addiction. 

Although most of this chapter has focused on prescription sleep aids, there are a few prescription medications available to help you stay awake. The most commonly used OTC stimulant is caffeine. However, people with the sleep disorder narcolepsy are very sleepy during the day (no matter how much sleep they get) and often require prescription stimulants to alleviate their sleepiness. Stimulants are also prescribed for the treatment of attention deficit/hyperactivity disorder (ADHD, sometimes called ADD), asthma, and obesity. 

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