Skin—score structures

In Fig. 11 results are given for sulfosuccinate surfactants of different molecular structure tested according to the Draize skin irritation procedure. The test method defines test scores verbally as described in Table 21. The data in Fig. 11 prove the nonirritant character of sulfosuccinates tested at 10% concentration. Similar results were found for another group of sulfosuccinates [103]... 

In comparison to the skin, the buccal mucosa offers higher permeability and faster onset of drug delivery, whereas the key features which help it score over the other mucosal route, the nasal delivery system, include robustness, ease of use, and avoidance of drug metabolism and degradation. The buccal mucosa and the skin have similar structures with multiple cell layers at different degrees of maturation. The buccal mucosa, however, lacks the intercellular lamellar bilayer structure found in the stratum corneum, and hence is more permeable. An additional factor contributing to the enhanced permeability is the rich blood supply in the... 

Interior Structural Fire Fighting The act of fire suppression and rescue inside buildings or enclosed structures where a fire has gone beyond the incipient stage. Intoxication state of being poisoned by a toxic chemical. Irritant The tenn refers to a chemical, which is not corrosive, but which causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. A chemical is a skin irritant if. when tested on the intact skin of albino rabbits by the methods of 16 CFR 1500.41 for four hours exposure or by other appropriate teclmiques, it results in an empirical score of five or more. A chemical is an eye irritant if so determined under the procedure listed in 16 CFR 1500.42 or other appropriate techniques. 

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