Empirical scoring

Bdhm H-J 1994 The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure J. Comp.-Aided Mol. Design 8 243-56... 

Fred (Openeye Software) conformational ensembles Gaussian or empirical score... 

ICM [64] pseudo-Brownian sampling and local minimization mbced force field and empirical score... 

I-J 1994. The Development of a Simple Empirical Scoring Fimction to Estimate the Binding istant for a Protein-ligand Complex of Known Three-Dimensional Structure. Journal of nputer-Aided Molecular Design 8 243-256. 

Eldridge M D, C W Murray, T R Auton, G V Paoliniand R P Mee 1997. Empirical Scoring Functions 1 The Development of a Fast Empirical Scoring Fimction to Estimate the Binding Affinity of Ligand in Receptor Complexes. Journal of Computer-Aided Molecular Design 11 425-445. 

RH Lathrop, TE Smith. Global optimum protein threading with gapped alignment and empirical pair score functions. I Mol Biol 255 641-665, 1996. 

H. J. BOhm and M. Stahl, Rapid empirical scoring functions in virtual screening... 

H. J. Bohm, The development of a simple empirical scoring function to estimate the... 

A number of investigations have found that personality disorders are not very distinct from each other (on both conceptual and empirical levels) or from normal personality (Clark Watson, 1999). The lack of distinctiveness from normal personality presents a fundamental challenge to the categorical approach. However, most of this evidence is indirect (e.g., lack of clear bimodality in the distribution of scores on personality disorder criteria). Taxometrics is unique in its potential to provide direct empirical evidence that can help resolve the discontinuity question. Surprisingly, only one taxometric study has been conducted on this topic to date. 

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