Skin contact with hydrogen fluoride

In the event of accidental contact of hydrogen fluoride with the skin, the affected area must be washed immediately and... 

Speed in removing the victim from the contaminated atmosphere or removing the vapor or liquid from the skin or eyes is essential. First aid must start immediately in all cases of contact with the particular gas in any form. All affected persons should be referred to a physician, no matter how slight the injury, and the physician should be given a detailed account of the accident As soon as possible, more thorough medical treatment should be administered by a physician, preferably one familiar with hydrogen fluoride exposure treatment [3]. 

Precaution Wear rubber, neoprene or nitrile gloves, safely goggles avoid skin, eye contact incompat. with hydrogen fluoride, strong bases Hazardous Decomp. Prods. Irritating fumes, org. add vapors, silicon dioxide, formaldehyde... 

Burns. Skin bums resulting from contact with pure fluorine gas are comparable to thermal bums and differ considerably from those produced by hydrogen fluoride (114). Fluorine bums heal much more rapidly than hydrofluoric acid bums. 

Because of the hazardous nature of anhydrous hydrogen fluoride, adequate precautions should he taken to protect the head, eyes, and skin. Rubber gloves, an apron, and a plastic face mask are strongly recommended. All operations should be carried out in a hood. If hydrogen fluoride comes in contact with the skin, the contacted area should be thoroughly washed with water and then immersed in ice water while the patient is taken to a physi-... 

May cause severe and painful irritation of the eyes, nose, throat, and lungs. Severe exposure can cause accumulation of fluid in the lungs (pulmonary edema). Inhalation toxicity similar to hydrogen chloride and hydrogen fluoride. May cause second or third degree burns upon short contact with skin surfaces. Oral ingestion may result in tissue destruction of the gastrointestinal tract. Decreased blood cholinesterase levels have been reported in animals. 

Caution Phenylsulfur trifluoride and by-products (e.g., hydrogen fluoride from hydrolysis) are toxic, and all manipulations should be carried out in a good hood. Silva difluoride is a powerful oxidative fluorinating agent and reacts vigorously with many organic materials. These reagents should not be allowed to come in contact with the skin. 

Caution Anhydrous hydrogen fluoride is toxic and in contact with skin can cause serious burns. This preparation should he carried out in a well-ventilated hood. Rubber gloves and safety... 

The injury caused by chlorine trifluoride is in part attributed to its hydrolysis products, including chlorine, hydrogen fluoride, and chlorine dioxide. Effects in humans have not been reported but may be expected to be very severe inhalation may cause pulmonary edema, and contact with eyes or skin may cause severe burns. 

Hydrogen fluoride is a dangerous material. Its effects are serious if large quantities are inhaled or if it is allowed to remain in contact with the skin. If unwashed and untreated, a small drop of the aqueous acid on the skin will cause a painful wound. The effects are not felt... 

Both anhydrous hydrogen fluoride gas and hydrofluoric acid are highly corrosive and dangerous. Skin contact by even dilute aqueous HF can be severely injurious, causing deep ulceration with delayed effect. The acid can penetrate the skin and destroy tissues. It also is damaging to eyes, nose and lungs. Inhalation can cause fluorosis and pulmonary edema. 

The checkers recommend that, if hydrogen fluoride comes in contact with the skin, the contacted area be thoroughly washed with water and then immersed in ice water while the patient is taken to a physician. 

Tungsten hexafluoride is an irritating and corrosive gas. In the presence of moisture, hydrogen fluoride may be formed. Special care should be taken to avoid inhalation of the vapors or contact with skin. For disposal of tungsten hexafluoride, it can be diluted with an inert gas and scrubbed in water and a caustic solution. Small amounts of tungsten hexafluoride can be decomposed by passing through columns of soda lime or slaked lime. 

The most dangerous solvents in SPPS when using t-Boc chemistry are hydrogen fluoride (HF) and trifluoroacetic acid (TFA). HF is extremely dangerous and requires a special HF apparatus of Teflon-coated vessels to be handled safely. TFA and TFMSA in contact with skin also cause wounds that take weeks to heal. 

SAFETY PROFILE An inhalation hazard. Mildly toxic by an unspecified route. An experimental teratogen. Experimental reproductive effects. A skin and eye irritant. Flammable in the form of dust when exposed to flame. The powdered metal may ignite on contact with air or oxidants (e.g., bromine pentafluoride, bromine, chlorine trifluoride, potassium perchlorate, potassium dichromate, nitryl fluoride, fluorine, oxygen difluoride, iodine pentafluoride, hydrogen sulfide, sodium peroxide, lead(IV) oxide). 

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