Skin absorption, lethality

Symptoms appear much more slowly from skin absorption. Skin absorption great enough to cause death may occur in 1-2 h. Respiratory lethal dosages kill in 1-10 min, and liquid in the eye kills nearly as rapidly. Very small skin dosages sometimes cause local sweating and tremors but little other effects. Nerve agents are cumulative poisons. Repeated exposure to low concentrations, if not too far apart, will produce symptoms. 

The approximate lethal dose for skin absorption in pregnant rats and rabbits was 7.5 and 5.0g/kg, respectively Cutaneous application of DAIAC resulted in a marked incidence of embryo mortality at doses that did not affect maternal body weight or produce any signs of maternal toxicity. Teratogenic effects (three fetuses from one dam with encephalocele one of eight with diffuse subcutaneous edema) were found in rats only when DMAC was applied on gestation days 10 and 11 at a total dose of 2400 mg/kg. In another study, DMAC administered... 

Brittelli MR, Culik R, Dashiell OL, Fayerweather WE Skin absorption of hexafluoroacetone Teratogenic and lethal effects in the rat fetus. Toxicol Appl Pharmacol 47 35M0, 1979... 

Almost all reports of fatalities from malathion have involved ingestion The acute oral lethal dose is estimated to be somewhat below l.Og/kg. Nonlethal intoxication has occurred in agricultural workers but usually has been the result of gross exposures with concomitant skin absorption. 

Hydrogen cyanide is extremely toxic hy ingestion, inhalation, skin absorption, and all routes of exposure. An oral dose of 50 mg could be lethal to humans (Patnaik, P. 1999. A Comprehensive Guide to the Hazardous Properties of Chemical Substances, 2nd ed.. New York John Wiley). Symptoms from acute poisoning include labored breathing, shortness of breath, paralysis, unconsciousness, and respiratory failure. Lower doses can cause headache, nausea and vomiting. Oral LDsoin mice is 3.7 mg/kg. Amyl nitrite is an effective antidote. 

Methanol is widely used as a solvent and as a denaturing agent for ethanol and is also found in antifreeze. Mass poisonings have occurred because of ingestion in alcoholic drinks made with contaminated ethanol as well as from accidental exposure. Inhalation and skin absorption may cause toxicity. In humans, about 10 mL can cause blindness and 30 mL is potentially fatal, but there is variation in the lethal dose. 

Approximate lethal doses for rats and rabbits by single oral administration were between 420 and 620 mg kg respectively. The animals showed diarrhea, lethargy, and decreased respiration. Rabbits were reported to show diffuse degenerative changes in the brain, heart, liver, and adrenal glands necrosis of the epithelium of renal tubules and severe hyperemia and edema of the lungs by skin absorption. 

LDS0 Lethal Dosage, due to ingestion or skin absorption, at which approximately 50% of exposed test animals will die. 

Dicyclohexano-lS-crown-6, CMH36Oj, dicyclohexyl-18-crown-6". Causes eye, skin irritation in test animals. Approximate lethal dose in rats (mg/kg) 300 orally 130 skin absorption (Pedersen). 

Methylcyclohexanol is mildly toxic. Inhalation may produce mild irritation of the eyes and the respiratory system, and headache. Studies in rabbits showed that this compound could cause rapid narcosis and convulsion at sublethal doses. The minimum lethal dose by oral administration was 2000 mg/kg. Severe exposure may produce narcosis in humans. Skin absorption may canse dermatitis. 

Dichlorobenzene exhibits low acute toxicity by inhalation, ingestion, and skin absorption. It is more toxic than chlorobenzene. The symptoms are lacrimation, depression of central nervous system, anesthesia, and liver damage. Lethal concentration in rats for a... 

Piperidine is a highly toxic compound. The acute oral toxicity is high in many species of test animals. The oral LD50 values in mice and rabbits are 30 and 145 mg/kg, respectively (NIOSH 1986). The liquid is moderately toxic by skin absorption. Inhalation toxicity in experimental animals was low, however. A 4-hour exposure to 4000 ppm was lethal to rats. Piperidine is corrosive to skin. Contact with eyes can produce severe irritation. 

The toxicity data on pyrrole are scant. It is moderately toxic on test animals. The routes of exposure are inhalation of vapors, ingestion, and skin absorption. Vapors are an irritant to the eyes and respiratory tract. The lethal doses in rabbits by oral and dermal routes are within the range 150 and 250 mg/kg, respectively. 

Moderately toxic herbicide exhibited low to moderate toxicity in experimental animals when administered by oral, intraperitoneal, intravenous, and subcutaneous routes skin absorption is slow cholinesterase inhibitor in human ingestion can cause carbamate poisoning, which can be lethal when taken in large amount probable lethal oral dose in adult human estimated to be larger than other carbamate insecticides within the range... 

A derivative of DDT toxic properties similar to DDT systemic effects from ingestion include headache, anesthesia, cardiac arrhythmias, nausea, vomiting, sweating, and convulsions oral lethal dose in mice 600 mg/kg also moderately toxic by skin absorption susceptible to accumulation in fat sufficient evidence of carcinogenicity in experimental animals. 

Cholinesterase inhibitor highly toxic by ingestion and skin absorption exhibits acute, delayed, and chronic poisoning toxic symptoms include headache, blurred vision, pinpoint pupils, salivation, tearing, muscle spasms, vomiting, abdominal pain, diarrhea, seizure, shortness of breath, and respiratory arrest ingestion of 0.5-29 can cause death to adult humans median lethal dose (oral) in rat reported in the literature varies at... 

The lethal dose in rabbits by skin absorption is 300 mg/kg. The acute toxic symptoms in test animals include weakness, respiratory distress, convulsions, irritation of the gastrointestinal tract, and liver damage. 

Highly toxic by oral, ocular, inhalation, and skin absorption routes exposure to 27 ppm/4 hr was lethal to mice following lacrimation and somnolence ocular and oral intake prodnced tremor, convulsion, coma, and death subcutaneous dose of 15 mg/kg was lethal to mice LD50 oral (mice) 10 mg/kg LD50 skin (rabbits) ... 

Skin absorption and administration by intraperitoneal and intravenous routes exhibited high acute toxicity lethal dose in mice intraperitoneally was 4 mg/kg... 

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