Site investigation and monitoring

Wilson S. A. and Haines S. (2005) Site investigation and monitoring for groimd gas assessment - back to basics. Land Contamination and Reclamation, 13 (3), 211-22. 

The SW-846 methods are used in the RCRA compliance and monitoring programs for hazardous waste and stack gas characterization, groundwater monitoring, soil, surface water, and groundwater analysis during site investigation and remediation. Many laboratories adopted the SW-846 technical provisions as standards for routine operations. The fact that many of the SW-846 methods do not specify the acceptance criteria for analytical accuracy and precision and allow laboratories to use their own makes these methods even more attractive to the laboratories. 

H. J. Gottlieb el al. (ed.) Field Screening Europe Proc. of the first international conference on strategies and techniques for the investigation and monitoring of contaminated sites. Kluwer Academic. Dordrecht 1997. 

Bobrowsky PT, VanDine D, Bean S, Powell S, Lato M (in prep) Site investigation, analysis, monitoring and treatment—Canadian technical guidelines and best practices related to landslides a national initiative for loss reduction. Geological survey of Canada, Open file XXX... 

Binda L, Condoleo P, Tiraboschi C, Rigamonti P (2012) On-site investigation and crack monitoring of an ancient bell-tower. In Proceedings of the 14th international conference on structural faults repair (SF R-2012), Edinburgh. Scotland... 

Close tracking of data entry means that performance measures can be tracked and managed. Such measures typically include query rates (which can be tracked by site, investigator, quesiton, and any comparators), time to respond to queries, rate of query rejection, and the like, and they provide an opportunity to identify and correct performance issues, whether associated with an individual site or study or a program. This capability alone provides a powerful tool by which sites throughout the world can be closely monitored. 

Numerous studies have been published on the in vivo metabolism of peptides. However, these studies are concerned mainly with assessment of pharmacokinetic parameters such as half-life and clearance. Only seldom is the in vivo biotransformation of peptides that contain only common amino acids investigated in any detail, due to the difficulty of monitoring products of proteolysis that are identical to endogenous peptides and amino acids. More importantly, such studies fail to yield mechanistic and biochemical insights. For this reason, we begin here with a discussion of the metabolism of just a few peptides in some selected tissues, namely portals of entry (mouth, gastro-intestinal tract, nose, and skin), plasma, organs of elimination (liver, kidney), and pharmacodynamic sites (brain and cerebrospinal fluid). These examples serve as introduction for the presentation in Sect. 6.4.2 of the involvement of individual peptidases in peptide metabolism. 

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