Biochemical Insights

however, the emphasis will be on enzyme inhibitors per se, as they pertain to cancer cell metabolism — that is, inhibitors or blockers for certain critical biochemical reactions occurring in the conversion of glucose to pyruvic acid or pyruvate, and then to lactic acid or lactate. 

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Novotny M., Ma W., Zidek L. and Daev E. (1999). Recent biochemical insights into puberty acceleration, estrus induction, and puberty delay in the house mouse. In Advances in Chemical Signals in Vertebrates (Johnston R.L., Miiller-Schwarze D. and Sorenson P., eds.), pp. 99-116. 

Numerous studies have been published on the in vivo metabolism of peptides. However, these studies are concerned mainly with assessment of pharmacokinetic parameters such as half-life and clearance. Only seldom is the in vivo biotransformation of peptides that contain only common amino acids investigated in any detail, due to the difficulty of monitoring products of proteolysis that are identical to endogenous peptides and amino acids. More importantly, such studies fail to yield mechanistic and biochemical insights. For this reason, we begin here with a discussion of the metabolism of just a few peptides in some selected tissues, namely portals of entry (mouth, gastro-intestinal tract, nose, and skin), plasma, organs of elimination (liver, kidney), and pharmacodynamic sites (brain and cerebrospinal fluid). These examples serve as introduction for the presentation in Sect. 6.4.2 of the involvement of individual peptidases in peptide metabolism. 

Introduces the human genome. Biochemical insights derived from the human genome are integrated throughout the text. 

Law J. H., Ribeiro J. M. and Wells M. A. (1992) Biochemical insights derived from insect diversity. Annu. Rev. Biochem. 61, 87-111. 

Fortunately, the need to amass coordinates of atoms in reported crystal structures has already been appreciated, and efficient computer-based databases are now available. As a result, it is not necessary to type large sets of numbers into a computer, because they can be derived in computer-ready form from a database. In addition to the ready access to atomic coordinate tables, there are many excellent computer-graphics, geometrical, and statistical programs available for comparisons of structures. In practice, however, it is additionally advantageous to build molecular models either of the ball-and-stick variety or the space-filling variety, if chemical or biochemical insight is required from a comparison of molecular structures observed by crystal structure analyses. 

Sola, R.J., Rodriguez-Martinez, J.A., Griebenow, K. Modulation of protein biophysical properties by chemical glycosylation Biochemical insights and biomedical implications. Cell Mol. Life Sci. 2007, 64, 2133-52. 

If time is of the essence, the concerned reader may wish to skip directly to the last chapter. Chapter 11, and at the same time consider that there is a datk side to conventional treatments. For biochemical insights of a more technical nature. Chapter 3 is more specific.)... 

Palumbo A, d Ischia M, Misuraca M, Prota G (1992). Skin Pigmentation by Hydroquinone A Chemical and Biochemical Insight. Pigment Cell Res 2 299... 

RECENT BIOCHEMICAL INSIGHTS INTO PUBERTY ACCELERATION, ESTRUS INDUCTION, AND PUBERTY DELAY IN THE HOUSE MOUSE... 

An x-ray structure is not available for the monooxygenase tyrosinase, but spectroscopic and biochemical insights reveal its active site to be very... 

It is quite striking that our current biochemical insight into the enzymatic reaction of histone tail acetylation, the causative agents of this modification (Section IV.C), and their involvement in transcriptional control in vivo is not paralleled by a similar understanding of the stmctural effects of histone tail hyperacetylation on chromatin, or of the mechanistic underpinnings of the general stimulatory effect that this modification has on the transcriptional machinery. 

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