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Simple alcohols

Volatile, simple alcohols may be submitted to TLC only in the form of their 3,5-dinitrobenzoate esters (DNB-esters). These can be satisfactorily separated on silica gel G layers, using cyclohexane-carbon tetrachloride-ethyl acetate (10 + 75 + 15) under standard conditions (Fig. 184). Detection is carried out by spraying the layer with rhodamine [Pg.660]

B reagent and then inspecting in UV light. The DNB-esters are conveniently prepared by the procedure worked out by WAiiDi [89]  [Pg.661]

as often the case, the alcohols occur in aqueous solution, they are first extracted with alcohol-free ether The extract is dried over freshly ignited sodium sulphate, 3,5-dinitrobenzoyl chloride added and refluxed for 30 min. Unreacted acid chloride is then removed by adding water and 6—10% sodium hydroxide is added to adjust the pH to 9—10. The ether layer, containing the DNB-ester, is separated in a separating funnel and the aqueous layer extracted three to four times with alcohol-free benzene The combined ether and benzene extracts are dried over sodium sulphate and evaporated to dryness. The residue is taken up in a small, accurately measured amount of benzene this solution can be chromatographed directly. [Pg.661]

For the analysis of plasticisers, Braun [5] has recommended transesterification of the esters with 3,5-dinitrobenzoic acid, so as to obviate saponification and isolation of the alcohol. [Pg.661]

Procedure 2 ml of the plasticiser under investigation are mixed with 2 drops concentrated sulphuric acid and 1.5 g 3,5-dinitrobenzoic acid and heated 30 min on an oil bath at 150° C. After cooling, the mass is dissolved in 25 ml ether and the resultant solution washed with 25 ml 5% sodium carbonate and then with water. The ether is evaporated off, whereby the 3,5-dinitrobenzoate sometimes crystallises out and can be recrystallised if necessary. Otherwise the dark, oily residue after evaporation of the ether can be dissolved in a little ether and chromatographed directly. [Pg.661]


Fischer esterification is reversible and the position of equilibrium lies slightly to the side of products when the reactants are simple alcohols and carboxylic acids When the Fis cher esterification is used for preparative purposes the position of equilibrium can be made more favorable by using either the alcohol or the carboxylic acid m excess In the following example m which an excess of the alcohol was employed the yield indicated IS based on the carboxylic acid as the limiting reactant... [Pg.638]

Nitrations are highly exothermic, ie, ca 126 kj/mol (30 kcal/mol). However, the heat of reaction varies with the hydrocarbon that is nitrated. The mechanism of a nitration depends on the reactants and the operating conditions. The reactions usually are either ionic or free-radical. Ionic nitrations are commonly used for aromatics many heterocycHcs hydroxyl compounds, eg, simple alcohols, glycols, glycerol, and cellulose and amines. Nitration of paraffins, cycloparaffins, and olefins frequentiy involves a free-radical reaction. Aromatic compounds and other hydrocarbons sometimes can be nitrated by free-radical reactions, but generally such reactions are less successful. [Pg.32]

Nonionic surfactants are often characterized ia terms of their hydrophi1 e—1 ipophi1 e balance (HLB) number (see Emulsions). For simple alcohol... [Pg.245]

Optically Active Acids and Esters. Enantioselective hydrolysis of esters of simple alcohols is a common method for the production of pure enantiomers of esters or the corresponding acids. Several representative examples are summarized ia Table 4. Lipases, esterases, and proteases accept a wide variety of esters and convert them to the corresponding acids, often ia a highly enantioselective manner. For example, the hydrolysis of (R)-methyl hydratropate [34083-55-1] (40) catalyzed by Hpase P from Amano results ia the corresponding acid ia 50% yield and 95% ee (56). Various substituents on the a-carbon (41—44) are readily tolerated by both Upases and proteases without reduction ia selectivity (57—60). The enantioselectivity of many Upases is not significantly affected by changes ia the alcohol component. As a result, activated esters may be used as a means of enhancing the reaction rate. [Pg.337]

Optically Active Alcohols and Esters. In addition to the hydrolysis of esters formed by simple alcohols described above, Hpases and esterases also catalyze the hydrolysis of a wide range of esters based on more complex and synthetically useful cycHc and acycHc alcohols (Table 5). Although the hydrolysis of acetates often gives the desirable resolution, to achieve maximum selectivity and reaction efficiency, comparison of various esters is recommended. [Pg.338]

As a group, the MlC-causing bacteria may use almost any available organic carbon molecules, from simple alcohols or sugars to phenols to wood or various other complex pcJymers as food (heterotrophs), or they may fix CO9 (autotropha) as do plants. Some use inorganic elements or ions (e.g., NH or NO, CH, H, S, Fe, Mu, etc.), as sources of... [Pg.2420]

MeO)2CH2, LiBr, TsOH, CH2CI2, 23°, 83% yield. In this case a 1,3-methylene acetal is formed in preference to a 1,2-methylene acetal from a 1,2,3-triol. These conditions, also protect simple alcohols as their MOM derivatives. [Pg.119]

Silyl-derived protective groups are also used to mask the thiol function. A complete compilation is not given here since silyl derivatives are described in the section on alcohol protection. The formation and cleavage of silyl thioethers proceed analogously to simple alcohols. The Si—S bond is weaker than the Si—O bond, and therefore sulfur derivatives are more susceptible to hydrolysis. For the most part silyl ethers are rarely used to protect the thiol function because of their instability. Silyl ethers have been used for in situ protection of the — SH group during amide formation. ... [Pg.297]

Another area of gas-phase substituent effects that has attracted interest is the acidity of simple alcohols. In the gas phase, the order is r-BuOH > EtOH > MeOH 3>... [Pg.245]

The principal complications in the dehydration of simple alcohols arise through the possibilities of rearrangement and alternative directions for elimination. [Pg.320]

Rydon and co-workers (73) have shown that the reaction of simple alcohols with triphenylphosphite methiodide and triphenylphosphite dihalides gives alkyl halides according to the general scheme. [Pg.180]

Simple alcohols are named by the IUPAC system as derivatives of the parent alkane, using the suffix -ol. [Pg.601]

Compounds with a smaller/C., and larger pKa are less acidic, whereas compounds with a larger/Ca and smaller plsubstituent groups can have a significant effect, tert-Butyl alcohol is a weaker acid, for instance, and 2,2,2-trifluoroethanol is stronger. Phenols and thiols, the sulfur analogs of alcohols, are substantially more acidic than water. [Pg.603]

Monosaccharides behave as simple alcohols in much of their chemistry. For example, carbohydrate -OH groups can be converted into esters and ethers, which are often easier to work with than the free sugars. Because of their many hydroxyl groups, monosaccharides are usually soluble in water but insoluble in organic solvents such as ether. They are aiso difficult to purify and have a tendency to form syrups rather than crystals when water is removed. Ester and ether derivatives, however, are soluble in organic solvents and are easily purified and crystallized. [Pg.988]

Note. This excellent method, which proceeds with the intermediacy of the trimethylsilyl carboxylates, is equally applicable to esterifications of acids with simple alcohols, which are then used as solvent. [Pg.71]

For maximum selectivity, low temperatures are essential under such conditions, simple alcohols, even allylic, are unaffected, and with unsaturated lactones as substrates, the double-bond position stays unchanged. [Pg.74]

Application of the bromine substitution reaction allows the synthesis of aminoamides, alkoxyamides of simple alcohols and sugars, depsipeptides and (NH) pseudopeptides, C2 symmetric compounds. [Pg.160]

For the majority of redox enzymes, nicotinamide adenine dinucleotide [NAD(H)j and its respective phosphate [NADP(H)] are required. These cofactors are prohibitively expensive if used in stoichiometric amounts. Since it is only the oxidation state of the cofactor that changes during the reaction, it may be regenerated in situ by using a second redox reaction to allow it to re-enter the reaction cycle. Usually in the heterotrophic organism-catalyzed reduction, formate, glucose, and simple alcohols such as ethanol and 2-propanol are used to transform the... [Pg.52]

Note also that dialkyl ketones such as acetone and 3-pentanone are slightly more acidic than the simple alcohols in DMSO. Use of alkoxide bases in DMSO favors enolate formation. For the amide bases, -K b-h) << a(c-H)> and complete formation of the enolate occurs. [Pg.5]

Carboxylic acids can also be protected as orthoesters. Orthoesters derived from simple alcohols are very easily hydrolyzed, and the 4-methyl-2,6,7-trioxabicyclo[2.2.2]octane structure is a more useful orthoester protecting group. These... [Pg.275]

Fig. 29. Schematic representation of the longitudinal cross-section of the inclusion channel for the simple alcohol inclusions of 1 with MeOH, EtOH, and 2-PrOH 2). Hatched triangles and dotted squares represent polar areas (cf. Fig. 19, type Ila), while the rest is of apolar property... Fig. 29. Schematic representation of the longitudinal cross-section of the inclusion channel for the simple alcohol inclusions of 1 with MeOH, EtOH, and 2-PrOH 2). Hatched triangles and dotted squares represent polar areas (cf. Fig. 19, type Ila), while the rest is of apolar property...
The reaction does not normally take place with ketones under these conditions (i.e. with simple alcohols), but they can often be made to react with 1,2-diols, e.g. (25), to form cyclic acetals (26) ... [Pg.210]


See other pages where Simple alcohols is mentioned: [Pg.6]    [Pg.84]    [Pg.145]    [Pg.245]    [Pg.394]    [Pg.408]    [Pg.2]    [Pg.37]    [Pg.248]    [Pg.808]    [Pg.183]    [Pg.350]    [Pg.60]    [Pg.62]    [Pg.325]    [Pg.60]    [Pg.7]    [Pg.1065]    [Pg.15]    [Pg.19]    [Pg.301]    [Pg.152]    [Pg.85]    [Pg.90]    [Pg.27]   
See also in sourсe #XX -- [ Pg.3 ]

See also in sourсe #XX -- [ Pg.144 , Pg.145 , Pg.150 , Pg.160 , Pg.175 ]




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