Similarity measures position dependent

The B score (Brideau et al., 2003) is a robust analog of the Z score after median polish it is more resistant to outliers and also more robust to row- and column-position related systematic errors (Table 14.1). The iterative median polish procedure followed by a smoothing algorithm over nearby plates is used to compute estimates for row and column (in addition to plate) effects that are subtracted from the measured value and then divided by the median absolute deviation (MAD) of the corrected measures to robustly standardize for the plate-to-plate variability of random noise. A similar approach uses a robust linear model to obtain robust estimates of row and column effects. After adjustment, the corrected measures are standardized by the scale estimate of the robust linear model fit to generate a Z statistic referred to as the R score (Wu, Liu, and Sui, 2008). In a related approach to detect and eliminate systematic position-dependent errors, the distribution of Z score-normalized data for each well position over a screening run or subset is fitted to a statistical model as a function of the plate the resulting trend is used to correct the data (Makarenkov et al., 2007). 

Several studies have shown that clustering also occurs around negative ions in supercritical fluids. The mobility data for C F in xenon [see Fig. 3(a)] indicate that the clusters around C F are slightly smaller [see Fig. 3(b)] than those around the positive ion but the pressure dependence is similar. Measurements of the mobility of in argon at a temperature just above the critical temperature indicated the O2 ion also moves with a large solvation shell. 

The partially oxidized sihcon species are responsible for the anodic current transient measured at the end of etching of an anodic oxide film-covered n-Si electrode in the dark as shown in Fig. 3.25. For a clean n-Si surface, the anodic current is very small. This dark current during the etch-back experiment, whose peak position depends on the thickness, occurs on anodic oxide as well as on thermal oxide. The data shown in Fig. 3.25 indicate that the anodic reaction proceeds by injection of electrons from the partially oxidized sihcon species at the sihcon/oxide interface. The amount of charge associated with the current transient, which is similar for anodically and thermally oxidized surface, is about 4.4 x 10 C/cm corresponding to two monolayers of on a (100) surface. The partially oxidized species may extend to a number of atomic layers, fewer for thermal oxide than anodic oxide as shown in Fig. 3.25. 

Molecular quantum similarity measures, as formulated in integral (1), are dependent on the relative position of both studied molecules in space. Consequently, a procedure capable of arranging the molecular coordinates needs to be established. Two methodologies have been implemented to deal with this question the maximal similarity rule (MSR) [71], which considers that the optimal orientation corresponds to the one that maximizes the value of integral (1) and the topo-geometrical superposition algorithm... 

Because of differences in charge collection time, throughput wiU also depend on the size of the detector. The same source of data summarized in Table 14.4 also provided information about similar measurements made on a 140 % relative efficiency p-type GEM detector. In general, the differences in performance were similar to those shown in Table 14.4, but when optimized for resolution, the DSP suffers a much greater resolution loss at high connt rate. Peak position stability for the analogue system was much worse than for the smaller detector, but the DSP... 

Witiiin any approximation level, TDQS measures will depend on the relative positions in space of the three molecular structures involved. An integral maximum will be reached when the three molecules are optimally superposed, in a similar way as previously discussed within the CQS3 of Ihe CQS series involving two molecular stmctures. 

The TJV spectra were measured for practically all the numerous derivatives. Beside the analytical application of these to demonstrate the position of the substituent no detailed interpretation was attempted, however. On the whole, they are similar to the spectra of analogous purine derivatives and also display a similar dependence on Despite the fact that the question of structure with regard to the lactim-lactam (or thiolactim-thiolactam) tautomerism has not been studied in detail, it can be assumed that oxygen and sulfur derivatives, at variance with the conventional way of writing the formulas, possess a lactam or thiolactam structure. This is in agreement with the views on the analogous purine derivatives. 

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