Simian adenovirus

The compounds SbCls and SbClf were reported to be genotoxic in the rec-assay with B. subtilis. Sb(III)ac-etate enhanced the Simian-Adenovirus-7-mediated transformation of SHE-cells, and enhanced rates of chromosomal breaks in human leukocytes were reported after treatment with potassium antimony tartarate (APT). SbCl3 did not induce DNA/pro-tein-crosslinks in V79-cells and peripheral human lymphocytes. 

A useful in vitro transformation assay which may be particularly applicable for metals, is the the enhancement of hamster embryo cell transformation by simian adenovirus. Casto, et al (46) and DiPaolo et al ( ) reported that all metal salts (of a series of 38 tested) with known carcinogenic activity, increased the frequency of simian adenovirus SA-7 induced transformations. 

Cooper, J. E. K., Yohn, D. S., and Stich, H. F., 1968, Viruses and mammalian chromosomes A comparative study of the chromosome damage induced by human and simian adenoviruses, Exp. Cell Res. 53 225. 

Kit, S., Dubbs, D. R., deTorres, R. A., and Melnick, J. L., 1965, Enhanced thymidine kinase activity following infection of green monkey kidney cells by simian adenoviruses, simian papovaviruses and an adenovirus-SV40 hybrid virus. Virology 27 453. 

Gallimore, P.H., R.J.A. Grand, and P.J. Byrd, Transformation of human embryo retinoblasts with simian virus 40, adenovirus and ras oncogenes. Anticancer Res., 1986, 6, 499-567. 

Flint, S. J., Beltz, G. A., and Linzer, D. I. H., 1983, Synthesis and processing of simian virus 40-specific RNA in adenovirus-infected, simian virus 40-transformed human cells, J. Mol. Biol. 167 335. 

DNA sequence 13, 4 San Miguel sea lion virus see Caliciviruses Satellite plant viruses 77, 3 Satellite tobacco necrosis virus 77, 3 Serological methods use in virus research 77, 4 Sigma virus (Drosophila) 12, 1 Simian virus 40 adenovirus hybrid 13, 7 DNA sequence 13, 4 genetics 9, 1... 

Abbreviations Ad, Adenovirus EBV, Epstein-Barr virus FeLV, Feline leukemia virus FeSV, Feline sarcoma virus GaLV, Gibbon ape lymphosarcoma virus HVA, Herpesvirus ateles HVS, Herpesvirus saimiri MV, Monkey virus PML, Progressive multifocal leukoencephalopathy associated with three SV40-like viruses SSV-1, Woolly monkey fibrosarcoma virus SV, Simian virus. [Adapted from (477)]. 

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