Simethicone

Dow Corning Q7-2243 LVA Dow Corning Q7-2587 poly-dimethylsiloxane-silicon dioxide mixture Sentry Simethicone-, simeticone. [Pg.652]

Antifoaming agent tablet diluent water-repelling agent. [Pg.652]

The main use of simethicone as an excipient is as an antifoaming agent in pharmaceutical manufacturing processes, for which 1-50 ppm is used. [Pg.652]

Therapeutically, simethicone is included in a number of oral pharmaceutical formulations as an antiflatulent, although its therapeutic benefit is questionable. It is also included in antacid products such as tablets or capsules. In some types of surgical or gastroscopic procedures where gas is used to inflate the body cavity, a defoaming preparation containing simethicone may be used in the area to control foaming of the fluids. [Pg.652]

When simethicone is used in aqueous formulations, it should be emulsified to ensure compatibility with the aqueous system and components. [Pg.652]

Chemical Name Dimethyl polysiloxane Common Name — [Pg.1375]

Trade Name Manufacturer Country Year Introduced [Pg.1375]

Dimethyl diethoxy silane Trimethyl ethoxy silane Sodium hydroxide [Pg.1375]

Alcohol was then distilled off, until the temperature reached 100°C. 1,706.6 grams of distillate was collected (theory 1,430 grams). This alcohol was poured into four times its volume of water and an insoluble oil separated (457 grams). The insoluble fraction was added back to the copolymer residue from the distillation and 555 cc of 20% hydrochloric acid was added. The acid mixture was refluxed for two hours, and the silicon oils were carefully washed with distilled water until neutral. The yield was 1,420 grams (theory, 1,469 grams). [Pg.1375]

Patent 2,441,098 May 4, 1948 assigned to Corning Glass Works [Pg.1375]

Sample preparation Add formulation (oral liquid or crushed tablet) to 25 mL dichloro-methane and 25 mL diluted HCl (2 1), shake vigorously for 5 min, let stand for 1 h. Dry 5 mL of the lower organic layer over 500 mg anhydrous sodium sulfate, filter (0.45 (xm nylon), inject an aliquot of the filtrate. [Pg.579]

Mobile phase Gradient. MeCNrchloroform from 45 55 to 15 85 over 5 min, return to initial conditions over 5 min, re-equilibrate for 5 min. (Caution Chloroform is a carcinogen ) [Pg.579]

Detector Evaporative Light Scattering Detector, Alltech model 500, drift tube 95, nebxdizer 2 L/min [Pg.579]

Edwards, A. Elliss, R. A RP-LC method with evaporative light scattering detection for the assay of simethicone in pharmaceutical formulations, J.Pharm.Biomed.Anal., 2002, 30, 273-278. [Pg.579]

Sentry Simethicone Union Carbide Cotp. sihcone defoamers for antiflatulent preparations... [Pg.464]

Phazyme-PB 15/100 charcoal/bismuth/barbetis /hydrastis amylase / protease /Hpase / simethicone / phenobarbital Reed and Carnrick... [Pg.313]

Therapeutic Function Antiflatulent Chemical Name Dimethylpolysiloxane Common Name Simethicone... [Pg.500]

Simethicone (Mylicon) and charcoal are used as anti-flatulents (against flatus or gas in the intestinal tract). Simethicone has a defoaming action that disperses and prevents the formation of mucus-surrounded gas pockets in tiie intestine Charcoal is an absorbent that reduces the amount of intestinal gas. [Pg.473]

Antiflatulents are used for die relief of painful symptoms of excess gas in the digestive tract. These drugs are useful as adjunctive treatment of any condition in which gas retention may be a problem (ie, postoperative gaseous distention, air swallowing, dyspepsia, peptic ulcer, irritable colon, or diverticulosis). In addition to its use for tiie relief of intestinal gas, charcoal may be used in the prevention of nonspecific pruritus associated with kidney dialysis treatment and as an antidote in poisoning. Simethicone is in some antacid products, such as Mylanta liquid and Di-Gel liquid. [Pg.474]

ANTIFLATULENTS. Activated charcoal can adsorb drugs while they are in the GI tract. The nurse administers charcoal 2 hours before or 1 hour after other medications. If diarrhea persists or lasts longer than 2 days or is accompanied by fever, the nurse notifies the primary care provider. Simethicone is administered after each meal and at bedtime... [Pg.481]

Take simethicone after each meal and at bedtime. Thoroughly chew tablets because complete particle dispersion enhances antiflatulent action. [Pg.483]

Citrocarbonate Effervescent Granules—sodium bicarbonate, sodium citrate anhydrous Di-Gel Liquid—aluminum hydroxide, simethicone, saccharin, sorbitol, parabens... [Pg.679]

Extra Strength Maalox Suspension—aluminum hydroxide, magnesium hydroxide, simethicone, parabens, sorbitol, saccharin... [Pg.679]

Gaviscon Extra Strength Reliever Formula Liquid—aluminum hydroxide, magnesium carbonate, parabens, EDTA, saccharin, sorbitol, simethicone, sodium alginate... [Pg.679]

Mylanta Liquid—simethicone, sorbitol Nephrox Liquid—aluminum hydroxide, mineral oil Original Alka-Seltzer Effervescent Tablets—sodium bicarbonate, aspirin, citric acid, phenylalanine Riopan Plus—magaldrate, simethicone, sorbitol, sucrose Riopan Plus Suspension—magaldrate, simethicone, saccharin, sorbitol... [Pg.679]

Rulox Plus—aluminum hydroxide, magnesium hydroxide, simethicone, sugar, saccharin, dextrose Rulox Suspension—aluminum hydroxide, magnesium hydroxide, parabens, sorbitol, saccharin Simaal Gel 2 Liquid—aluminum hydroxide, magnesium hydroxide, simethicone... [Pg.679]

Tempo—aluminum hydroxide, magnesium hydroxide, calcium carbonate, simethicone, sorbitol, corn syrup... [Pg.679]

DEC2003 18DEC2003 Hydrocortisone Cream 102 06JAN2004 08JAN2004 Simethicone... [Pg.107]

Danhof IE, Stavola JJ. 1974. Accelerated transit of intestinal gas with simethicone. Obstet Gynecol 44 148-154. [Pg.180]

Silyl-terminated polyethers, 22 38-39 Silyl-terminated polyisobutylene, 22 39 Simethicone... [Pg.847]

Available 20 mg simethicone tablets weighing 150 mg each, pheno-barbital powder, and 500 mg magnesium carbonate tablets weighing 1 g each. [Pg.132]

After consulting the physician, phenobarbital dose is reduced to 0.025 g. 1800 mg powder of simethicone from 12 tablets, 300 mg of phenobarbital powder, 1200 mg of magnesium carbonate powder from two tablets and 600 mg of lactose are needed for the 12 capsules. Size of the capsules is 1. [Pg.355]

Simethicone is an antigas ingredient in many liquid and solid pharmaceutical preparations, and FTIR is used in quality assurance laboratories to determine whether its concentration is at the specified level. A sample of the product is dispersed in an HC1 solution and the simethicone extracted from this solution with toluene. The toluene solutions are then run on the FTIR using a liquid sampling cell. For the quantitative analysis, a simethicone absorption band that is free from interference from the toluene absorption bands is used in a manner similar to that of the isopropyl alcohol band in Experiment 26. [Pg.225]

Dave Segura prepares to use an FTIR instrument for simethicone analysis. Notice the liquid sampling cell in Dave s left hand. [Pg.225]

See also in sourсe #XX -- [ Pg.180 ]

See also in sourсe #XX -- [ Pg.1130 ]

See also in sourсe #XX -- [ Pg.665 ]

See also in sourсe #XX -- [ Pg.223 , Pg.244 , Pg.652 ]

See also in sourсe #XX -- [ Pg.645 ]

See also in sourсe #XX -- [ Pg.627 , Pg.627 , Pg.652 ]

See also in sourсe #XX -- [ Pg.292 , Pg.293 , Pg.294 ]

See also in sourсe #XX -- [ Pg.369 , Pg.370 , Pg.371 ]

See also in sourсe #XX -- [ Pg.579 ]

See also in sourсe #XX -- [ Pg.246 ]

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