Selected Ion Monitoring SIM

SHR Spontaneously hypertensive rat SIM Selected ion monitoring SIRS Soluble immune response suppressor... 

SIM, selected ion monitoring SRM, selected reaction monitoring MRM, multiple reaction monitoring. 

PDMS = polydimethylsiloxane. PA = polyacrylate. CW = Carbowax. DVB = divinylbenzene. FID = flame ionization detection. NPD = nitrogen-phosphorus detection. TSD = thermionic-specific detection. LOQ = limit of quantitation. LOD = limit of detection. TCA = trichloroacetic acid. PICI-MS = positive ion chemical mass spectrometry. SIM = selected ion monitoring. 

ECD = electron capture detection EPA = Environmental Protection Agency GC = gas chromatography GPC - gel permeation chromatography HRMS = hihg-resolution mass spectrometry MID = multiple ion detection MS = mass spectrometry SIM = selected ion monitoring... 

H2SO4 = sulfuric acid IDL = insturmental detection limit MS = mass spectrometry MSD = mas selective detctor Na2S04 = sodium sulfate PCBs = poylchiorinated biphenlys PUR = polyurethane foam SIM = selective ion monitoring SPE = solid phase extraction... 

TD-IT, Thermal desorption-ion trap CAD MIKE, collisionally activated decomposition mass-analyzed ion kinetic energy MID, multiple ion detection FID, flame ionization detector NPD, nitrogen/phosphorus detector SIM, selected ion monitoring El, electron impact TMS, trimethylsilane MTBSTFA, N-methyl-N-(tetr.-butyldimethylsilyl)trifluoroacetamide. 

SD standard deviation SDE simultaneous distillation extraction SDS sodium dodecyl sulfate SFC solid fat content SFI solid fat index SHAM salicylhydroxamic acid SIM selected ion monitoring SNIF-NMR site-specific natural isotope fractionation measured by nuclear magnetic resonance spectroscopy SP-HPLC straight-phase high-performance liquid chromatography... 

For abbreviation of analyte names see Sect. Abbreviations . ACN acetonitrile, APCI atmospheric pressure chemical ionization, dial, microdialysis samples, ESI electrospray ionization, FA formic acid, iso isocratic, IT ion trap, lin range linear range, MeOH methanol, MRM multiple reaction monitoring, MS full scan mass spectrometry, n.s. not specified, OAc acetate, QqQ triple quadrupole mass spectrometer, SIM selected ion monitoring, Solv HPLC solvent, SQ single quadrupole mass spectrometer, T temperature Ratios given as v/v... 

Fig. 5 Statistical evaluation of LC-MS-based methods for tropane alkaloids referred in this chapter. (a) Relative frequency of ionization methods. +APCI positive atmospheric pressure chemical ionization, +ESI positive electrospray ionization, FAB fast atom bombardment, +TSP positive thermospray, (b) Relative frequency of scan modes used. MS full scan MS, MS/MS tandem mass spectrometry (product ion scan), MRM multiple reaction monitoring, SIM selected ion monitoring, (c) Relative frequency of mass analysers used. EBQtQ2 double focusing sector field mass spectrometer, IT ion trap, QqQ triple quadrupole, SQ single quadrupole. Considered publications were found by PubMed data-based search and references cited in these articles...

As mentioned previously, the formation of the methyl derivative is similar to several methods that already have been developed for organotin pesticides. The utilization of this derivative in conventional gas chromatographic residue procedures presents many challenges. Electron capture detection is sensitive enough but requires extensive clean-up while with FID and FPD the sensitivity is lower than desired. The development of a routine GC/MS procedure (single or multiple ion monitoring) was chosen then as the only possible alternative. A SIM (selective ion monitoring) method is specific for retention time and as well as for characteristic ions (m/e). 

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