Sigmodon hispidus

McMurry, S.T., R.L. Lochmiller, S.A.M. Chandra, and C.W. Qualls, Jr. 1995. Sensitivity of selected immunological, hematological, and reproductive parameters in the cotton rat (Sigmodon hispidus) to subchronic lead exposure. Jour. Wildl. Dis. 31 193-204. 

Deer mouse, Peromyscus maniculatus white-footed mouse, P. leucopus cotton rat, Sigmodon hispidus <0.01 mg/kg whole-body fresh weight (FW), less skin and Gl tract 3... 

Savabieasfahani, M., R.L. Lochmiller, D.P. Rafferty, and J.A. Sinclair. 1998. Sensitivity of wild cotton rats (Sigmodon hispidus) to the immunotoxic effects of low-level arsenic exposure. Arch. Environ. Contam. Toxicol. 34 289-296. 

Pelton, M.R. and E.E. Provost. 1969. Effects of radiation on survival of wild cotton rats (Sigmodon hispidus) in enclosed areas of natural habitat. Pages 39-45 in D J. Nelson and F.C. Evans (eds.). Symposium on Radioecology. Proceedings of the Second National Symposium. Available as CONF-670503 from The Clearinghouse for Federal Scientific and Technical Information, Natl. Bur. Standards, Springfield, VA 22151. 

In other rodents, subordinate males also smell scent marks quite often and so keep informed on the presence, status and activities of higher-ranking group members. For instance, dominant males of the hispid cotton rat, Sigmodon hispidus, urine mark more than subordinates. The social status of the male urine donor affects the response of other males to the odor. The response of a reproductive female to feces of either sex depends on her dominance status (Gregory and Cameron, 1989). 

Gregory, M. J. and Cameron, G. N. (1989). Scent communication and its association with dominance behavior in the Hispid cotton rat [Sigmodon hispidus). Journal of Mammalogy 70,10-17. 

Field Studies. We have attempted to compare the relative availability of actinides to small mammals living in contaminated environments near ORNL. Shrews, rats and mice have been collected from a 30 year old contaminated floodplain forest ecosystem ( ). Cotton rats (Sigmodon hispidus) have been collected from the banks of a former liquid radioactive waste pond which contains Pu, Am and Cu in sediments and shoreline vegetation. Analyses were performed by isotope dilution mass spectrometry (U, Th and Pu) or by alpha spectrometry (Pu, Am and Cm). 

Litomosoides carinii of cotton rats, Sigmodon hispidus... 

Prince GA, Porter DD, Jenson AB, Horswood RL, Chanock RM, Ginsberg HS. Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J Virol 1993 67 101-11. 

McMurry ST, Lochmiller RL, Vestey MR, et al. 1991. Acute effects of benzene and cyclophosphamide exposure on cellular and humoral immunity of cotton rats, Sigmodon hispidus. Bull Environ Contain Toxicol 46(6) 937-945. 

Brown Norway rat, Rattus norvegicus, 337 Cotton rat, Sigmodon hispidus, 692 Desert woodrat, Neotoma lepida, 803 Heermann s kangaroo rat, Dipodomys heermanni, 803... 

The cotton rat (Sigmodon hispidus) is a well-established model for a number of human pathogens, especially viral respiratory pathogens (14,15). The model detailed in this chapter is an adaptation of a model of S. aureus nasal colonization originally described in mice (16) but now adapted to cotton rats. The cotton rat s nasal histology is comparable to that of humans (17) and pretreatment of cotton rats with antibiotics like streptomycin is not required as it is in mice (16) to establish nasal colonization by S. aureus. We have successfully used the cotton rat S. aureus nasal colonization model to demonstrate the efficacy of lysostaphin as a therapy for S. aureus nasal colonization (18) as well as to study the roles of wall teichoic acid (19) and IsdA and IsdH (20) of S. aureus in nasal colonization. 

Cotton rats (Sigmodon hispidus) (14) may be purchased from Harlan (Hsd Cotton Rat, Indianapolis, IN). There are also several breeding colonies that may be able to provide animals, including colonies at Virion Systems (Gaithersburg, MD) and Baylor College of Medicine (Houston, TX). Cotton rats should be 6 weeks old or older for use in this model (see Note 1). 

Niewiesk, S. and Prince, G. (2002) Diversifying animal models the use of hispid cotton rats (Sigmodon hispidus) in infectious diseases. Lab. Anim. 36, 357-372. 

Shrimps, thiaminase in, X, 75 Sigmodon hispidus kispidus, see under Cotton rat... 

Radiation ecologists have attached various types of dosimeters to small animals in an attempt to estimate the radiation dose. Kaye (1965) studied the use of silver-activated metaphosphate-glass dosimeters, which measure dose by radiophotoluminescence, in ecological research at Oak Ridge National Laboratory. These solid-state dosimeters, measuring 1x6 mm, were injected subcutaneously into cotton rats (Sigmodon hispidus) (Figure 19a). The rats were... 

Figure 46. Preliminary models of the tissue distribution of IUDR and Na I in the cotton rat (Sigmodon hispidus) 48 hr postinjection, (a) IUDR (b) Na I. From O Farrell and Dunaway (1967).

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