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Side-products dimeric

When doing this method the scientists confirmed something that has long been theorized by those who study these sorts of things. That is, they determined that if one tries to convert all of the catechol at once like was done in the above method then it tends to form a dimer side product like that shown below [120]. [Pg.217]

Two extreme mechanisms can be envisaged (Scheme 12), concerted [2 + 2] cycloaddition or the more generally accepted formation of a dipolar intermediate (164) which closes to a /3-lactam or which can interact with a second molecule of ketene to give 2 1 adducts (165) and (166) which are sometimes found as side products. In some cases 2 1 adducts result from reaction of the imine with ketene dimer. [Pg.259]

The reaction of benzoxazine in die presence of 2,6-xylenol does not occur until 135 C, presumably because die hydrogen-bonded intermediate depicted for the 2,4-xylenol reaction (Fig. 7.19) cannot occur. All three types of linkages are obtained in diis case. Para-para methylene-linked 2,6-xylenol dimers, obtained from the reaction of 2,6-xylenol with formaldehyde, formed in the decomposition of the benzoxazine (or with other by-products of that process) dominate. Possible side products from benzoxazine decomposition include formaldehyde and CH2=NH, either of which may provide the source of methylene linkages. Hie amount of ortho-para linkages formed by reaction of 2,6-xylenol with benzoxazine is low. Ortho-ortho methylene-linked products presumably form by a decomposition pathway from benzoxazine (as in Fig. 7.18). [Pg.393]

Despite of the disadvantage, that at least one symmetrical dimer is formed as a major side product, mixed Kolbe electrolysis has turned out to be a powerful synthetic method. It enables the efficient synthesis of rare fatty acids, pheromones, chiral building blocks or non proteinogenic amino acids. The starting compounds are either accessible from the large pool of fatty acids or can be easily prepared via the potent methodologies for the construction of carboxylic acids. [Pg.106]

This mechanism, which has been mostly studied with diaryl ketones, is more hkely for aromatic and other conjugated aldehydes and ketones than it is for strictly aliphatic ones. Among the evidence" for the SET mechanism are ESR speetra" and the faet that At2C—CAt2 side products are obtained(from dimerization of the... [Pg.1208]

The selectivity for cross-dimerization relative to the dimerization of AMS, was found to be better with the acid-treated clay catalyst Engelhard F-24 than with the ion-exchange resin catalyst Amberlyst-15. Also, the formation of undesired side products, i.e. diisoamylenes, was lower in the case of Engelhard F-24 than for Amberlyst-15. [Pg.137]

Dopamine /3-hydroxylase (D/3H) is a copper-containing glycoprotein that hydroxylates dopamine at the benzylic position to norepinephrine.84 During the attempted crystallization of the bis(hydroxide)-bridged dicopper(II) dimer, a side product was subsequently isolated (complex (63)), revealing intramolecular hydroxylation at a formally benzylic position of the tris(imidazo-lyl)phosphine ligand.85 The copper(II) center has an axially compressed TBP structure. [Pg.759]

Heated in methanol for an extended period of time, propargyl azide 1147 experiences a [3,3] sigmatropic shift to allenyl azide 1148 that undergoes rapid cyclization to triazafulvene 1149. Addition of a molecule of methanol converts reactive intermediate 1149 to triazole 1150 that is isolated in 68% yield. In concentrated solutions, two molecules of intermediate 1149 may undergo cycloaddition to form dimer 1151 as a side product (Scheme 189) <2005EJ03704>. [Pg.129]

The side products of the reaction between benzoylnitromethane 279 and dipolarophiles (norbornene, styrene, and phenylacetylene) in the presence of l,4-diazabicyclo[2.2.2]octane (DABCO) were identified as furazan derivatives (Scheme 72). The evidence reported indicates that benzoylnitromethane gives the dibenzoylfuroxan as a key intermediate, which is the dimerization product of the nitrile oxide. The furoxan then undergoes addition to the dipolarophile, hydrolysis, and ring rearrangement to the final products (furazans and benzoic acid) <2006EJ03016>. [Pg.371]

The 3,4-bis(4-fluorophenyl)-l,2,5-oxadiazole 2-oxide 324 was found as a side product in the synthesis of isoxazole derivatives (Scheme 82, method A) <2006AXEo4827>. Dimerization of 3- and 4-nitrobenzonitrile A-oxides gave corresponding 1,2,5-oxadiazole A-oxides (Scheme 82, method B) <1999MI111>. [Pg.380]

Two repeated exposures of resin 38 to the catalyst (9% mol) for 18 h in dichloromethane at room temperature afforded the expected allyl lactoside in an encouraging isolated yield of 81% from resin 35 (90% per step). Traces of dimerized compounds resulting from cross-metathesis were detected as the only side products. Extension of the oligosaccharide chain was subsequently performed first by deacetylation (excess NaOMe in 4/1 CH2Cl2/MeOH at r.t.) and glycosylation with known lactosyl donor 40 in conditions similar to those mentioned above. Cleavage was performed twice as described above, but with a reduced reaction time of 6 h in this case tetrasaccharide 42 was isolated in 51% yield from 35 (84% per step). No dimerized products were detected. [Pg.79]

Several examples are known of the transition metal-catalyzed synthesis of 1,2,3-buta-trienes, which possess one more cumulated C=C double bond than allenes. Most of the reported examples of the butatriene synthesis involve dimerization of terminal alkynes and conjugated enynes are typical side products of the reactions. [Pg.133]

Starting materials can be defined as the raw materials that form the basis of a chemical reaction as a part of the synthesis of an intermediate in the production of a drug substance. Catalysts typically include any material added to a mixture to accelerate, control, or otherwise modify a chemical reaction. Intermediates are those products of a synthesis scheme that will undergo further reaction. By-products are the side-products of a chemical reaction, and may include conjugates, dimers, enantiomers, unintended salts or free-bases, over-substitution, others. These types of impurities are usually considered to be process impurities and are not expected to increase in concentration over time. [Pg.362]

To prevent the latter mentioned subsequent reactions, the bulky phos-phaalkyne Ph C P as well as tungsten alkoxides of reduced size as, e.g., [W2(ONp)6] were employed in these three-component reactions with no significant success [15]. The crucial steps for the side-product free synthesis of the phosphido complexes 18 are the introduction of a phosphaalkyne possessing a moderate steric bulkiness, which lies between those of f-BuC=P and Ph C P, and resulting from the P-NMR studies (cf. Eq. 5), a reaction temperature mode allowing the complete metathesis reaction to take place at very low temperatures over a long period of time until all the phosphaalkyne has been converted into the metathesis products (about 12 h) only then is the reaction mixture allowed to reach room temperature. We found that MesC=P meets these steric requirements, and the three-component-reaction between MesC=P, [W2(Of-Bu)6] and [M(CO)5(thf)] (M = Cr, W), carried out at -78 °C and warmed up to ambient temperature within 15 h, succeeded in the synthesis and isolation of the phosphido complex 18a,b (Scheme 2) [15]. Furthermore, if t-BuC=P is incorporated into these reactions, the steric requirements of the alkoxide dimer has to be slightly increased. Thus, f-BuC=P reacts with [W2(OPh )6] and [M(CO)5(thf)] (M=Cr, W) under the... [Pg.14]

The tetranuclear osmium(VI) oxo imido complex [(Bu N)20s(/u-NBu )20s(NBu )(/u-0)]2 (2) is obtained as a side product in the reaction of [OSO4] with neat NHBu (SiMe3) (Scheme 1). Its structure can be described as a dimer of dimers with Cjh symmetry. ... [Pg.750]

Since the hydroformylation reaction for most substrates shows a first order dependence on the concentration of rhodium hydride, the reaction becomes slower when considerable amounts of rhodium are tied up in dimers. This will occur at low pressures of hydrogen and high rhodium concentrations. Dimer formation has mainly been reported for phosphine ligands [17, 42, 45], but similar dimeric rhodium complexes from monophosphites [47] and diphosphites [33, 39] have been reported. The orange side product obtained from HRh(15)(CO)2 was characterized as the carbonyl bridged, dimeric rhodium species Rh2(15)2(CO)2 [39]. [Pg.251]

Problems do, however, occur during cyclization with all-L- or all-D-residues (see Section 6.8.1.3.1). Cyclodimerization can be triggered by an extended backbone conformation of the linear precursor, and C-terminal epimerization derived from slow amide bond formation. These lead to dimers or epimerized side products. 73,241 Cyclization of such tetrapeptides are successful only in a few exceptional cases.1169,73 To overcome this problem, protection of the backbone amide with Boc has been proposed since this approach favors the c/s-amide bond configuration which induces one or more suitable conformations for cyclization. 69 As a consequence, the cyclization yield of c[-Ala-]4 242 improved from 1 to 27% 69 (see also the use of Al-Hmb protection in Section 6.8.1.3.1). [Pg.476]

Alkylthieno[2,3-4furans 414 and 4-alkylfuro[3,4-, ]furans 416 were obtained as unexpected side products from the reaction of 2-acetyl-5-bromothiophene and 2-acetyl-5-methylfuran with stabilized and nonstabilized ylides, along with the corresponding phosphoranes 415, pyrans 417, and dimeric products 418, respectively (Scheme 45) <2000T7573>. [Pg.45]

Substituted cyclopropylidenes have been shown to participate in both inter-and intramolecular addition reactions with olefins. The resulting products are spiropentane derivatives as well as carbene dimers which are formed as side-products [99, 100]. In the absence of olefinic reaction products the latter may even become the main products [99 b],... [Pg.51]

The formation of propene oxide as a side product of the acrolein formation or dimerization reactions is reported by many authors. Daniel et al. [95,96] demonstrated that propene oxide is formed by surface-initiated homogeneous reactions which may involve peroxy radical intermediates. The epoxidation is increased by a large void fraction in the catalyst bed or a large postcatalytic volume. In view of these results, the findings of Centola et al. [84] are understandable, as the wall of the empty reactor may have been sufficiently active to initiate the reaction. [Pg.136]

Further to its ability to perform allylic and benzylic oxidations,149 /-butylpcroxy-iodane (6) effects radical oxidation of 4-alkylphenols to give 2,5-cyclohexadien-l-ones under mild conditions in good yields.150 o,o-Coupling dimers as side products and inhibition of the reaction by added galvinoxyl radical scavenger support a radical oxidation mechanism. [Pg.192]


See other pages where Side-products dimeric is mentioned: [Pg.103]    [Pg.105]    [Pg.555]    [Pg.556]    [Pg.135]    [Pg.27]    [Pg.84]    [Pg.235]    [Pg.69]    [Pg.628]    [Pg.674]    [Pg.602]    [Pg.115]    [Pg.326]    [Pg.401]    [Pg.612]    [Pg.59]    [Pg.575]    [Pg.339]    [Pg.256]    [Pg.261]    [Pg.371]    [Pg.464]    [Pg.744]    [Pg.295]    [Pg.145]   
See also in sourсe #XX -- [ Pg.116 ]




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