Sialic acid receptors

Gal/GalNAc or Man/GlcNAc, there are also receptors (e.g., the macrophage sialic acid receptor) for the recognition of sialylated complex glycans.10... 

Virus binds sialic acid receptors on host surface. 

Compounds derived from a cyclopentane or pyrrolidine skeleton have recently been attracting close attention as next-generation neuraminidase inhibitors [121,122,123,124,125], and active efforts have been made for screening of such compounds (O Scheme 18). Attempts have also been made to prevent virus infection by removing the tracheal sialic acid receptors (the starting point of viral infection) through direct inhalation of sialidase [126]. 

Patterson, S., Smith, B.D., Taylor, R.E. Tuning the affinity of a synthetic sialic acid receptor using combinatorial chemistry Tetrahedron Lett., 1998, 39, 3111-3114... 

Modulation of sialic acid-receptor interactions, e g., increase of the binding of murine B lymphocyte CD22 adhesin and of Escherichia coli K99 lectin decrease of the binding of mouse macrophage sialoadhesin and Myelin-Associated Glycoprotein (MAG) [664-667]... 

Sialic acid receptors of microorganisms, plants and lower animals. . . ... 

H1-H16) and 9 different neuraminidases (N1-N9). Except for the Thogotovirus genus, all orthomyxoviruses bind to sialic acid receptors. The receptor of an influenza A virus of subtype H17N10 isolated recently from bats [13] is not known. 

Fetuin (a bovine embryonic glycoprotein especially rich in terminal sialic acid) to check for the specifity of sialic acid receptor reactions of LFA and MAA lectins. 

Influenza vims A has two surface glycoproteins that offer potential for the development of competitive multivalent sugar clusters featuring 5-A -acetyl neuraminic acid (Neu5Ac) units [35]. Haemagglutinin (HA) binds to sialic acid receptors and fuses the cell membranes of the vims and host and neuraminidase (NA), an enzyme, cleaves sialic acid residues and is involved in release of new vims by the host cell. Whilst small molecule inhibitors of NA, such as oseltamivir (Tamiflu) and zanamavir (Relenza), are now available, no therapy based on inhibition of binding of HA has reached the clinic. 

Feng ZP, Zhang X, Han P, Arora N, Anders RF, Norton RS. Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes. Mol Biochem Parasitol. 2006 150(2) 256-267. Matrosovich M, Herrler G, Klenk HD. Sialic acid receptors of viruses. Top Curr Chem. 2013. 

Smith has prepared a grafted polymer containing a ribonucleoside 5 -tripho-sphate selective sensor. The polymers were prepared using poly(allylamine) (PAA) to which 10% of boronic add monomer unit 202 was grafted.Also, a library of potential sialic acid receptors was prepared. In this case, the polymers were prepared using PAA to which 2% of the boronic acid monomer unit 202 was grafted. The final polymers also contained various amounts of 4-hydroxybenzoic acid, 4-imidazolacetic acid, octanoic acid and/or succinic anhydride. 

Reduction of sialidase, trans sialidase and sialate-pyruvate lyase activities Hindrance of sialic acid receptor interactions (viruses, mammals)... 

The nature of mycoplasma receptor sites on erythrocytes or other mammalian cells has not been extensively investigated. Of seventeen mycoplasma serotypes investigated, four bind to putative sialic acid receptors (Manchee and Taylor-Robinson, 1969). Mycoplasma pneumoniae and Mycoplasma gallisepticum appear to attach to sialic acid receptors on the erythrocytes or tracheal epithelial cells. Pretreatment of... 

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