Combinatorial chemistry using

S. W. Kaldor, M. G. Siegel, Combinatorial Chemistry using Polymer supported Reagents , Cun. Opin. Chem Bio. 1997,1,101. 

Kaldor, S. W. Siegel, M. Combinatorial Chemistry Using Polymer-Supported Reagents, Curr. Opin. Chem. Biol. 1997, 7,101. 

Intelligent Design in Combinatorial Chemistry Use of Designed Peptide Libraries to Explore Secondary and Tertiary Structures in Peptides and Proteins... 

Kaldor SW, Siegel MG. Combinatorial chemistry using polymer-supported reagents. Curr. Opin. Chem. Bio. 1997 1 101-106. 

Detection schemes will also continue to evolve. While NMR is covered in another chapter in this volume, advances in NMR used as an LC detector have also been reported (25-28) that may eventually increase the utility of this tool for combinatorial chemistry. Used in both stopped flow and on line modes, LC/NMR can be extremely useful for structure elucidation provided the proper mobile phases or solvent suppression techniques are used (27). 

Combinatorial chemistry uses such methods to make mixtures of many possible compounds (called libraries) that can then be screened for the desired property to select those compounds that are active.149 The methods are suitable not only for polypeptides, but also for oligonucleotides,150 oligosaccharides,151 and a variety of small molecules, including many heterocyclic compounds. The method s popularity is because our knowledge of the inter-... 

A branch of combinatorial chemistry used for developing in an empirical or semi-empirical manner new and more efficient catalysts. 

Figure 11 Site-specific dynamic combinatorial chemistry uses disulfide exchange as the reversible reaction for inhibitor construction and an introduced thiol residue on the protein to help target the inhibitors to the binding sites of interest.

A novel methodology employing aza-Payne rearrangement and OJ<[-intramolecular acyl transfer reactions was reported by Tamamura et for the synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres (87). This method is also applicable for the synthesis of hydroxyethylamine dipeptide isosteres containing pseudopeptides and also for combinatorial chemistry using solid-phase techniques. 

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