Sialic acid binding adhesin

It should, however, be noted that despite this multitude of potential carbohydrate receptors, only two H. pylori adhesins have been identified to date, i.e., the Leb-binding adhesin BabA [16], and the sialic acid-binding adhesin SabA [8], An additional H. pylori carbohydrate binding protein is the soluble neutrophil-activating protein... 

Unemo, M., Aspholm-Hurtig, M., liver, D., Bergstrom, J., Boren, T., Danielsson, D., and Teneberg, S. (2005). The sialic acid binding SabA adhesin of Helicobacter pylori is essential for nonopsonic activation of human neutrophils. J. Biol. Chem. 280, 15390-15397. 

Abstract Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed. 

Modulation of sialic acid-receptor interactions, e g., increase of the binding of murine B lymphocyte CD22 adhesin and of Escherichia coli K99 lectin decrease of the binding of mouse macrophage sialoadhesin and Myelin-Associated Glycoprotein (MAG) [664-667]... 

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