Sensor Principles Based on High-Refractive-Index Optical Waveguides

Sensor Principles Based on High-Refractive-Index Optical Waveguides 

High-refractive-index materials enable the investigation of bioreactions at the surface within the evanescent field. Various sensor systems were developed with the advantage of high sensitivity and measurement in the presence of the sample without any rinsing. The sensor principles can be divided into label-free sensor systems where the determination of the effective refractive index is the pivotal parameter and systems based on surface-confined fluorescence excitation where the marker molecule is solely detected. 

---