Sense peptide

Cell permeabilization and uptake of anti-sense peptide-peptide nucleic acid (PNA) into Escherichia coli. J. Biol. Chem. 2002 277 7144-7147. 

Stock R. P., Olvera A., Sanchez R., Saralegui a., Scarei S., Sanchez-Lopez R., Ramos M.A., Boeea L.C., Benatti U., Alagon a. Inhibition of gene expression in Entamoeba histolytica with anti-sense peptide nucleic acid oligomers. Nature Biotechnol. 2001, 19 231-234. 

In that sense peptides represent a paramount example of how Nature diversifies from one single gene to generate multiple sets of biomolecules resulting from degradation of proteins by a complex network of proteases present in a living cell. 

The products from the translation of antisense RNA. Some antisense peptides have been demonstrated to show affinity properties that appear to be unique to that sequence and not seen in scrambled sequences. See Schwabe, C., New thoughts on the evolution of hormone-receptor systems, Comp. Biochem. Physiol. A 97, 101-106, 1990 Chaiken, I., Interactions and uses of anti-sense peptides in affinity technology, J. Chromatog. 597, 29-36, 1992 Labrou, N. and Clonis, Y.D., The affinity technology in downstream processing, J. Biotechnol. 36, 95-119, 1994 Root-Bernstein, R.S. and Holsworth, D.D., Antisense peptides critical mini-review, J. Theoret. Biol. 190, 107-119, 1998 Siemion, I.Z., Cebrat, M., and Kluczyk, A., The problem of amino acid complementarity and antisense peptides, Curr. Protein Pept. Sci. 5, 507-527, 2004. 

Oligonucleotide analogues have commonly been considered as nucleic acids even in the absence of an acidic group, e.g., methyl phosphon-ates. In a formal sense, peptide nucleic acids are neither peptides nor composed of nucleic acids, nor should they be confused with peptide/protein oligonucleotide conjugates as described in the previous section. The PNA monomeric unit contains features of both amino acids and nucleosides. The four common base portions of nucleosides—adenyl, cytosyl, guanidyl, and thymidyl—are tethered to the PNA backbone, which carries the functionality of common amino acids. Amide bonds then consecutively link these monomer units. The term polyamide is more chemically appropriate thus an alternative name is polyamide nucleoside analogue, which is still abbreviated PNA. 

By definition, a sense peptide is one whose sequence is coded for by the nucleotide sequence (read 5 3 ) of sense mRNA, whose sequence contains the same coding information as the sense strand of DNA. Gonversely, a complementary peptide is coded for by the nucleotide sequence (read 5 3 ) of complementary mRNA, with the same sequence information as the complementary strand of DNA. Frequently, sense and complementary peptides are capable of specific interactions, in a process that may involve an amino-acid interaction code embedded within the genetic code and its complement (Figure 7.40). One application of sense-complementary peptide interactions may be in the design of complementary... 

Therapeutic profile In mimicking the quorum-sensing peptides, the thiolactone peptides act as antibacterials, naturally regulating the growth of the bacteria. 

Petersen, F.C., Fimland, G., and Scheie, A.A. (2006). Purification and functional studies of a potent modified quorum-sensing peptide and a two-peptide bacteriocin in Streptococcus mutans. Mol Microbiol 61, 1322-1334. 

In the strict sense, opiates are drugs which are derived from opium and include the natural products morphine, codeine, thebaine and many semi-synthetic congeners derived from them. In the wider sense, opiates are morphine-like drugs with non-peptidic structures. The old term opiates is now more and more replaced by the term opioids which applies to any substance, whether endogenous or synthetic, pqrtidic or non-peptidic, that produces morphine-like effects through an action on opioid receptors. 

Ohuchi Y, Katayama Y, Maeda M (2001) Fluorescence-based sensing of protein kinase A activity using the dual fluorescent-labeled peptide. Anal Sci 17 il465—i 1467... 

---