Selenium glutathione

Chaudiere, J. and Tappel, A.L. (1984) Interaction of gold(I) with the active site of selenium-glutathione peroxidase. Journal of Inorganic Biochemistry, 20, 313—325. 

Roberts, J. and Shaw, C.F. Ill (1998) Inhibition of erythrocyte selenium-glutathione peroxidase by auranofin analogs and metabolites. Biochemical Pharmacology, 55, 1291-1299. 

Roberts,J.(1993)Thekineticpropertiesof Au(I) drug binding to serum albumin and selenium-glutathione peroxidase and their significance for rheumatoid arthritis. Ph.D. thesis, University-Milwaukee. 

Peroxidases (E.C. 1.11.1.7) are ubiquitously found in plants, microorganisms and animals. They are either named after their sources, for example, horseradish peroxidase and lacto- or myeloperoxidase, or akin to their substrates, such as cytochrome c, chloro- or lignin peroxidases. Most of the peroxidases studied so far are heme enzymes with ferric protoporphyrin IX (protoheme) as the prosthetic group (Fig. 1). However, the active centers of some peroxidases also contain selenium (glutathione peroxidase) [7], vanadium (bromoperoxidase)... 

Fisher A. B., Dodia C., Manevich Y., Chen J. W., and Feinstein S. I. (1999). Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidase. J. Biol. Chem. 

Chaudiere, J., Wilhelmsen, E. C., and Tappel, A. L. (1984). Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptans. J. Biol. Chem. 259, 1043-1050. 

Zhu, J.-H., and Lei, X. G. Double null of selenium-glutathione peroxidase-1 and copper,zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity. Exp. Biol. Med. 231 545-552, 2006. 

Michelson AM. 1998. Selenium glutathione peroxidase Some aspects in man. J Environ Pathol Toxicol Oncol 17(3 4) 233-239. 

Tappel A. 1984. Selenium-glutathione peroxidase Properties and synthesis. Curr Top Cell Regul 24 87-97. 

Monovalent gold salts impacted metabolism of seleifium, copper, and zinc. Intravenous Au" " may adversely affect the availability of seleifium for synthesis of selenoenzymes. Rats given gold sodium thiomalate iv at 25.0 or 50.0 xmol/kg BW had sigifificantly altered seleifium deposition, as measured by radioselenium-75. These effects included the almost complete cessation of Se exhalation as dimethyl sulfide and the accumulation of Se in blood plasma. Direct chemical reaction with nucleophilic selenium metabolites in the body may underlie these alterations. Auranofin inhibited selenium-glutathione peroxidase in bovine erythrocytes this enzyme... 

Pregnant long-tailed macaques (Macaca fascicularis) given L-selenomethionine for 30 days at doses of 25.0,150.0, or 300.0 (xg Se/kg body weight daily showed dose-dependent increases in erythrocyte and plasma selenium, glutathione peroxidase activities, hair and fecal selenium, and urinary selenium excretion. Adverse effects, including body weight loss, were associated with daily doses of 150.0 and 300.0 xg Se/kg BW and with concentrations of erythrocyte selenium >2.3mg/L,... 

Selenium Glutathione peroxidases Type I and III deiodinases Removal of H2O2 and hydroperoxides Conversion of thyroxine to active form... 

Selenium-Glutathione Peroxidase Properties and Synthesis Al L. Tappel... 

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