Selection of antibiotics

Rundlett, K. L. and Armstrong, D. W., Effect of micelles and mixed micelles on efficiency and selectivity of antibiotic-based capillary electrophoretic separations, Anal. Chem., 67, 2088, 1995. 

Patient Encounter, Part 3 Empirical Selection of Antibiotics... 

Selection of antibiotics should consider that up to 30% to 40% of H. influenzae and 95% of M. pneumoniae are /1-lactamase producers, and up to 30% of S. pneumoniae are at least moderately penicillin resistant. 

Baker-Austin C, Wright MS, Stepanauskas R et al (2006) Co-selection of antibiotic and metal... 

Armstrong JL, Calomiris JJ, SeidlerRJ (1982) Selection of antibiotic-resistant standard plate count bacteria during water treatment. Appl Environ Microbiol 44(2) 308-316... 

TABLE 1 The Selectivities of Antibiotic CSPs in the Three Mobile Phase Modes... 

Zhao X, Drlica K. Restricting the selection of antibiotic-resistant mutant bacteria measurement and potential use of the mutant selection window./. Infect. Dis., 2002, 185, 561-565. 

Other reports regarding the selection of antibiotic-binding aptamers, including aminoglycosides, have also recendy appeared (164-167). 

The bacterial selectivity of antibiotics pertains to an interference with prokaryotic protein synthesis as distinguished from eukaryotic protein synthesis (Muench, in Devlin, 1986, pp. 936,937). As has been indicated, however, some of the antibiotics are too toxic for clinical use, although useful in studying protein synthesis. 

ANTIBACTERIAL AGENTS A number of antibiotics have been formulated for topical ocular use (Table 63-2). Appropriate selection of antibiotic and route of administration is dependent on the patient s symptoms, the clinical examination, and the culture/sensitivity results. Specially formulated antibiotics also may be extemporaneously prepared by pharmacists for serious eye infections such as comeal infiltrates or ulcers and endophthalmitis. 

Indirect effects of residues in the environment, such as the selection of antibiotic-resistant microorganisms, cannot currently be ruled out. ... 

The Toolkit for Reduction of Clostridium difficile through Antimicrobial Stewardship assists hospital staff and leadership in developing an effective antimicrobial stewardship program (ASP) with the potential to reduce Clostridium difficile infection (C. difficile), a serious public health problan that has recently increased in both incidence and severity. An ASP is a systematic approach to developing coordinated interventions to reduce overuse and inappropriate selection of antibiotics, and to achieve optimal outcomes for patients in cost-efficient ways. ASPs targeted to C. difficile reduction show promise because increased rates of C. difficile are associated with inappropriate antibiotic use. 

Briones E, Colino Cl, Lanao JM (2008) Delivery systems to increase the selectivity of antibiotics in phagocytic cells. J Control Release 125 210-227... 

The results of these studies demonstrate the need for early initiation of broad-spectrum empirical antimicrobial therapy on suspicion of VAP. The American Thoracic Society (ATS) published its first guidelines for the management of hospital-acquired pneumonia in 1995. In 1998, Trouillet et al. (15) suggested a different classification for the prediction of pathogens and the selection of antibiotic treatment based on the use or not of previous antibiotic use and the duration of MV. These classifications provide different rationale for the prediction of... 

Pharmacokinetic and pharmacodynamic properties should be incorporated into the selection of antibiotics for the treatment of nosocomial pneumonia (12). 

S. K. Olofsson and O. Cars, Optimizing drug exposure to minimize selection of antibiotic resistance, Clin. Infect. Dis., 2007, 45(Suppl. 2), S129-S136. 

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