Selected reaction monitoring , mass

Holmes, M., Teo, S.L. and Khoo, H.W., Detection of diarrheic shellfish poisoning toxins from tropical shellfish using liquid chromatography-selected reaction monitoring mass spectrometry, Nat. Toxins., 1, 6, 361, 1999. 

SRM. selected reaction monitoring SSMS. spark source mass spectrometry... 

The most common modes of operation for ms/ms systems include daughter scan, parent ion scan, neutral loss scan, and selected reaction monitoring. The mode chosen depends on the information required. Stmctural identification is generally obtained using daughter or parent ion scan. The mass analyzers commonly used in tandem systems include quadmpole, magnetic-sector, electric-sector, time-of-flight, and ion cyclotron resonance. Some instmments add a third analyzer such as the triple quadmpole ms (27). 

The MS-MS equivalent of this technique is known as selected-decomposition monitoring (SDM) or selected-reaction monitoring (SRM), in which the fragmentation of a selected precursor ion to a selected product ion is monitored. This is carried out by setting each of the stages of mass spectrometry to transmit a single ion, i.e. the precursor ion by MSi and the product ion by MS3 (see Figure 3.8 above). 

Table 5.2 Selected-reaction monitoring (SRM) transitions nsed for MS-MS detection of the pesticides studied in the systematic investigations on APCI-MS signal response dependence on eluent flow rate. Reprinted from J. Chro-matogr.. A, 937, Asperger, A., Efer, J., Koal, T. and Enge-wald, W., On the signal response of various pesticides in electrospray and atmospheric pressure chemical ionization depending on the flow rate of eluent applied in liquid chromatography-mass spectrometry , 65-72, Copyright (2001), with permission from Elsevier Science...

Figure 5.66 Molecular structures of Idoxifene and its deutrated internal standard ds-Idoxifene. Reprinted from J. Chromatogr., B, 757, Comparison between liqnid chromatography-time-of-flightmass spectrometry and selected-reaction monitoring liqnid chromatography-mass spectrometry for qnantitative determination of Idoxifene in hnman plasma , Zhang, H. and Henion, I., 151-159, Copyright (2001), with permission from Elsevier Science.

Tian, Q. et al., Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring, J. Chromatogr. A, 1091, 72, 2005. 

Selected Reaction Monitoring (SRM) Data acquired from specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. Selected reaction monitoring can be preformed as tandem mass spectrometry in time or tandem mass spectrometry in space. The term multiple reaction monitoring is deprecated [1],... 

Moritz, T. Olsen, J.E. Comparison Between High-Resolution Selected Ion Monitoring, Selected Reaction Monitoring, and Four-Sector Tandem Mass Spectrometry in Quantitative Analysis of Gib-berellins in Milligram Amounts of Plant Tissue. Anal. Chem. 1995, 67, 1711-1716. 

LC/MS/MS with selected reaction monitoring and ESI in the negative-ion mode was used to detect RDX and its degradation products in contaminated groundwater [18]. The detected degradation products were MNX (hexahydro-l-nitroso-3,5-dinitro-l,3,5-triazine), DNX (hexahydro-l,3-dinitroso-5-nitro-l,3,5-triazine) and TNX (hexahydro-l,3,5-trinitroso-l,3,5-triazine). The [M + 75] and [M + 45] were the most intense ions in the mass spectra of RDX and its degradation products. In the CID mass spectra, the base peak for RDX, MNX and DNX... 

The use of MALDI for the analysis of small molecules was recently reported. Particularly attractive is the coupling of a MALDI source with a triple quadrupole mass analyzer for quantitative analysis in the selected reaction monitoring (SRM) mode due to very high analysis speed. 

Black, R. Henion, J. High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns. J Chromatogr B Anal Technol Biomed Life Sci 2003, 783, 73-83. 

Li, A. C. Alton, D. Bryant, M. S. Shou, W. Z. Simultaneously quantifying parent drugs and screening for metabolites in plasma pharmacokinetic samples using selected reaction monitoring information-dependent acquisition on a QTrap instrument. Rupid Commun Mass Spectrom 2005, 19, 1943-1950. 

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