Selected reaction monitoring , mass spectrometry

Selected Reaction Monitoring (SRM) Data acquired from specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. Selected reaction monitoring can be preformed as tandem mass spectrometry in time or tandem mass spectrometry in space. The term multiple reaction monitoring is deprecated [1],... 

Perri, E., A. Raffaelli, and G. Sindona. OE067 Quantitation of oleuropein in virgin olive oil by ionspray mass spectrometry-selected reaction monitoring. J OE068 Agr Food Chem 1999 47(10) 4156-4160. 

Because it uses two consecutive mass spectrometers, selected reaction monitoring is also called tandem mass spectrometry or mass spectrometry-mass spectrometry, or just MS-MS. 

SRM. selected reaction monitoring SSMS. spark source mass spectrometry... 

The MS-MS equivalent of this technique is known as selected-decomposition monitoring (SDM) or selected-reaction monitoring (SRM), in which the fragmentation of a selected precursor ion to a selected product ion is monitored. This is carried out by setting each of the stages of mass spectrometry to transmit a single ion, i.e. the precursor ion by MSi and the product ion by MS3 (see Figure 3.8 above). 

Table 5.2 Selected-reaction monitoring (SRM) transitions nsed for MS-MS detection of the pesticides studied in the systematic investigations on APCI-MS signal response dependence on eluent flow rate. Reprinted from J. Chro-matogr.. A, 937, Asperger, A., Efer, J., Koal, T. and Enge-wald, W., On the signal response of various pesticides in electrospray and atmospheric pressure chemical ionization depending on the flow rate of eluent applied in liquid chromatography-mass spectrometry , 65-72, Copyright (2001), with permission from Elsevier Science...

Figure 5.66 Molecular structures of Idoxifene and its deutrated internal standard ds-Idoxifene. Reprinted from J. Chromatogr., B, 757, Comparison between liqnid chromatography-time-of-flightmass spectrometry and selected-reaction monitoring liqnid chromatography-mass spectrometry for qnantitative determination of Idoxifene in hnman plasma , Zhang, H. and Henion, I., 151-159, Copyright (2001), with permission from Elsevier Science.

Tian, Q. et al., Screening for anthocyanins using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry with precursor-ion analysis, product-ion analysis, common-neutral-loss analysis, and selected reaction monitoring, J. Chromatogr. A, 1091, 72, 2005. 

Moritz, T. Olsen, J.E. Comparison Between High-Resolution Selected Ion Monitoring, Selected Reaction Monitoring, and Four-Sector Tandem Mass Spectrometry in Quantitative Analysis of Gib-berellins in Milligram Amounts of Plant Tissue. Anal. Chem. 1995, 67, 1711-1716. 

Holmes, M., Teo, S.L. and Khoo, H.W., Detection of diarrheic shellfish poisoning toxins from tropical shellfish using liquid chromatography-selected reaction monitoring mass spectrometry, Nat. Toxins., 1, 6, 361, 1999. 

Black, R. Henion, J. High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns. J Chromatogr B Anal Technol Biomed Life Sci 2003, 783, 73-83. 

Secondary ozonides see Final ozonides Selected reaction monitoring (SRM), mass spectrometry, 693 Selenides... 

Selected ion monitoring and selected reaction monitoring increase the selectivity of mass spectrometry for individual analytes and improve the sensitivity by decreasing the response to everything else (that is, decreasing background noise). Figure 22-20a shows a liquid... 

Figure 24-22 Selected reaction monitoring in gas chromatography-mass spectrometry, (a) Reconstructed total ion chromatogram of extract from orange peel with electron ionization, (b) Selected reaction monitoring with the precursor ion m/z 293 selected by mass filter Q1 in Figure 22-21 and product ion m/z 264 selected by mass filter Q3. The chromatogram is a graph of intensity at m/z 264 from Q3 versus time. [Courtesy Thermo Ftnnlgan GC ana GC/MS Division, San Jose. CA.J...

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