Select a Concept

You have now created a large number of concepts for the new product and just have to select the best one. .. If only it were so simple this is the point where many developments run into problems. Deciding what to develop - and what not - is far from easy. It can disrupt a team. 

The first difficulty is that decisions have to be taken before you have the products. At this point you do not know enough to make a proper decision A second difficulty is that one often has to compare ideas that are incomparable ideas of a very different level. A third difficulty occurs when team members invest time in a certain concept, and become attached to it. If their baby is killed this can lead to bad feelings. A fourth problem is not getting lost in the almost infinite number of ideas, variants and combinations that one might consider. 

Trying to select from a number of concepts nearly always gives rise to new ideas - and often not the worst ones. It would be foolish not to consider these, but it does disrupt the selection process. All these things can lead to indecision in the team, bad feelings and political compromises - usually with poor results. In this lesson we discuss methods that can help. However, do not expect miracles. Decision making remains difficult, even with a good method. 

Design and Development of Biological, Chemical, Food and Pharmaceutical Products J.A. Wesselingh, S. Kill and M.E. Vigild 2007 John Wiley Sons, Ltd 

Transplantation A possible way of dealing with diabetes would be to transplant cells or the complete organ that produces insulin in the body. 

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Select a Concept. Select one (or a few) from the many concepts, quantify the behaviour of the product, and set better specihcations. 

Selectivity, a concept related to specificity, is a measure of the extent to which the method can determine the analyte of interest in a biological matrix without interference from other constituents in the test sample (i.e., matrix components). Again, because LBAs determine analytes in the biological matrix without sample pretreatment, this methodology is prone to interference from components present in the sample matrix. Specificity and selectivity evaluations are conducted in prevalidation and confirmed early in prestudy validation. 

An alternative concept review, if needed, should be completed by the enterprise to select a concept or concepts to which the system definition activities described in 5.1.1.2 through 5.1.3.2 are to be applied. During this review, each concept is evaluated based on... 

Final state analysis is where dynamical methods of evolving states meet the concepts of stationary states. By their definition, final states are relatively long lived. Therefore experiment often selects a single stationary state or a statistical mixture of stationary states. Since END evolution includes the possibility of electronic excitations, we analyze reaction products in terms of rovibronic states. 

Ther (cp) dependence in the form of Eq. (5) makes it possible to describe any experimental data by selecting coefficients br But, nevertheless, formula (5) should be modified introducing a concept of maximum degree of loading cpm. This is due to the fact that the values of cp cannot reach 1, since very large values of cp are devoid of phy-... 

In the examples described above, the UltraLink is associated with the extracted concepts. To augment its flexibility and applicability, we allow for a dynamic UltraLink construction from a portion of text selected by the user. When the user selects a section of a document with the mouse, a list of UltraLinks is generated on the fly on release of the mouse button as shown in Figure 31.4A. Furthermore, the Web Interface allows for several UltraLink windows to be opened simultaneously as shown in Figure 31.4B. 

A concept named molecular manufacturing, which was originally proposed by K. Eric Drexler [99] in 1992, has attracted the attention of some investigators [100, 118-121]. Molecular manufacturing is defined as the production of complex structures via non-biological mechanosynthesis (and subsequent assembly operations) [99]. A chemical synthesis controlled by mechanical systems operating on the atomic scale and performing direct positional selection of reaction sites by atomic-precision manipulation systems is known as mechanosynthesis. 

E.M. Thurman, 1. Ferrer, and D. Barcelo, The ionization-continuum diagram a concept for selection of APCl and ESI conditions for HPLC/MS of pesticides , in 17th Montreux Symposium on Liquid Chromatography/Mass Spectrometry, Montreux, Switzerland, November 8-10, 2000 , p. 31 (2000). 

We evaluated a number of potential catalysts and conditions using xylitol as a model compound in a batch reactor. A catalyst was selected from this initial screening and examined in a continuous trickle-bed reactor to develop operating conditions. Finally, as resources allowed, the catalyst was evaluated in a trickle bed reactor to gain a concept of potential catalyst lifetime. 

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