Seed herbicide safener

Herbicide safeners (also referred to as herbicide antidotes or protectants) fulfill an important role in crop protection. Safeners are chemicals that protect crop plants from unacceptable injury caused by herbicides. Either by placement on the crop seed or by way of a physiological selectivity mechanism, safeners in commercial use do not negatively impact the weed control of the herbicide. Although many herbicides have been developed for use without a safener, some of the strongest and most broad-spectrum herbicides tend towards border-line crop selectivity, which may completely preclude use in a particular crop or at least limit maximum use rates or the crop varieties that can be safely treated. It is for such situations that safeners have been developed. Several books and reviews of safeners have been written over the past 20 years [1-3]. It is not the intention of this chapter to cover in detail older safeners, but rather to focus on more recently developed commercial safeners as well as some of the older compounds still in wide commercial usage. 

Direct-seeded rice does not tolerate pretilachlor in doses required for adequate weed control. The Ciba Geigy AG has discovered and developed a new safening agent, 4,6-dichloro-2-phenyl-pyrimidine (CGA123 407,23), which protects the rice seedling from damage and does not interfere with the herbicidal activity of pretilachlor. 

NA had also a stimulatory effect on the oxidative metabolism of the herbicide bentazone. Microsomal preparations of etiolated shoots from maize, which had received a seed treatment with NA, showed activity of a bentazone hydroxylase, which was not detectable in extracts from controls without safener pre-treatment [35]. Also, the improved tolerance of maize to the imidazolinone AC263222 after NA seed treatment could be related to enhanced AC 263222 hydroxylation by stimulation of a cytochrome P450 monooxygenase [31]. 

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