Se ■ ■ ■ N interaction

The intramolecular Se N interactions in complexes of the type 15.5 result in a downfield shift in the Se NMR resonances the magnitude of this shift corresponds approximately to the strength of the interaction. ... 

The methodology of heteroatom-directed lithiation has been applied to the synthesis of a variety of organochalcogen compounds, including unstable, low-valent compounds (Section 15.6). ° The Se N interactions in the diselenide 15.4 activate the Se-Se bond toward insertion of a sulfur atom or a methylene group to give the derivatives 15.21a,... 

Scheme 15.2 Stereochemical conti ol under the influence of an Se N interaction...

Chiral organoselenenyl halides may also be stabilized by intramolecular Se N interactions Se NMR chemical shifts indicate that these interactions are maintained in solution. ... 

Hz (DMSOd = 6) in [33](X = SeAr), i.e., they show opposite trends. On the other hand, TSJ(Se, F) depends strongly on temperature and in [33](X=CN) and in [33](X = SeAr), when using the same solvent, they follow similar trends. Similar Se-N non-bonded interactions were reported previously by the same authors278 in 2-selenobenzylamine derivatives where they measured J(Se, N) couplings transmitted through the non bonded Se-N interaction as large as... 

Mg levels Action Mg supl Dose 400-800 mg/d + daily—qid w/ full glass of H20 Caution [B, +] Contra Ulcerative colitis, diverticulitis, ileostomy/colostomy, heart block, renal insuff Disp Caps 140 mg tabs 400 mg (OTC) SE D, N Interactions Effects OF chlordiazepoxide, dicumarol, digoxin, indometliacin, INH, quinolones, tetracyclines EMS Monitor ECG for hypokalemia (flattened T waves) OD Unlikely to cause life-threatening Sxs, but may cause D, constipation, cramps, and abd pain symptomatic and supportive... 

Intramolecular chalcogen interactions may also stabilize reactive functional groups enabling the isolation of otherwise unstable species or their use as transient intermediates, especially in the case of selenium and tellurium. For example, tellurium(II) compounds of the type ArTeCl are unstable with respect to disproportionation in the absence of such interactions. The diazene derivative 15.23 is stabilized by a Te N interaction. Presumably, intramolecular coordination hinders the disproportionation process. Other derivatives of the type RTeX that are stabilized by a Te N interaction include 8-(dimethylamino)-l-(naphthyl)tellurium bromide, 2-(bromotelluro)-A-(p-tolyl)benzylamine, and 2-[(dimethylammo)methyl]phenyltellunum iodide. Intramolecular donation from a nitrogen donor can also be used to stabilize the Se-I functionality in related compounds." ... 

Transannular Te N interactions have also been employed to stabilize compounds of the type 15.24 with terminal Te=E (E = S, Se) bonds.The Te=Se bond length in 15.24b is 2.44 A (cf. 2.54 A for a Te-S single bond) and d(Te N) = 2.62 A. Intramolecular coordination was also employed in the isolation of the first aryl-selenenium and -tellurenium cations 15.25a,b as [PEg] salts. 

Effect of Cs+, a structure-breaking type cation In acidic medium, the silica anions will interact preferentially with the smallest positively charged entities which appear to be the hydrated Cs+ ions. Consequently, a small number of nuclei (because silicate-Pr N interactions are less preferred), essentially Si-rich (becau -se silicate-Al(H20) + interactions are less favoured) and containing very little Na (because silicate-Na(H20)x+ interactions are... 

Ciprofloxacin (Cipro, Cipro XR, Proquin XR) [Antibiotic/ Fluoroquinolone] Uses Rx lower resp tract, sinuses, skin skin structure, bone/joints, urinary tract Infxns including prostatitis Action Quinolone antibiotic DNA gyrase Dose Adults. 250-750 mg PO ql2h XR 500-1000 mg PO q24h or 200-400 mg IV ql2h in renal impair Caution [C, /-] Children <18 y Contra Component sensitivity Disp Tabs, susp, inj SE Restlessness, N/V/D, rash, ruptured tendons, T LFTs Interactions T Effects Wf probenecid T effects OF diazepam, theophylline, caffeine, metoprolol, propranolol, phenytoin, warfarin effects W/ antacids, didanosine, Fe salts. Mg, sucralfate, Na bicarbonate,... 

Uses Advanced breast CA in postmenopausal Action Nonst oidal aromatase inhibitor Dose 2.5 mg/d PO Caution [D, ] Contra PRO Disp Tabs SE Anemia, N, hot flashes, arthralgia Interactions t Risk of interference w/ action of drug W/ estrogens and OCPs EMS None OD May cause N s5rmptomatic and supportive... 

Uses Postpartum bleeding (uterine subinvolution) Action Ergotamine derivative Dose 0.2 mg IM after placental deliv y, may repeat 2-4-h intervals or 0.2-0.4 mg PO q6-12h for 2-7 d Caution [C, ] Contra HTN, PRO Disp Inj, tabs SE HTN, N/V Interactions t Vasoconstriction W/ ergot alkaloids, sympathomimetics, tobacco EMS Tobacco use can t vasoconstriction and lead to a hypertensive crisis OD May cause N/V/D, chest/abd pain, limb numbness, and possibly distal gangrene d/t vasoconstriction activated charcoal may be effective for PO form... 

Pyridoxine [Vitamin B ] [Vitamin B Supplement] U e Rx prevention of vit B6 deficiency Action Vit supl Dose Adults. Deficiency 10-20 mg/d PO Drug-induced neuritis 100-200 mg/d 25-100 mg/d prophylaxis Peds. 5-25 mg/d x 3 wk Caution [A (C if doses exceed RDA), +] Contra Component aUCTgy Disp Tabs 25, 50, 100 mg inj 100 mg/mL SE Allergic Rxns, HA, N Interactions -1- Effects OF levodopa, phenobarbital, phenytoin EMS Can be used as an antidote for isoniazid poisoning OD May cause sensory nerve damage (numbness, tingling, reduced sensation) and coordination problems Sxs are usually revised aft stopping pyridoxine symptomatic and supportive... 

Contra PRO, breast-feeding Disp Inj SE BM, N/V/D, drug fever, skin rash Interactions T Myelosuppression W/ cisplatin, other neoplastic drugs, radiation therapy T in duration of neutropenia W/ filgrastim EMS Monitor for S/Sxs of Infxn OD May cause N/V/D and profound BM suppression s5miptomatic and supportive... 

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