Scoparon

A. schottii Pohl/ stem EtOH/ Maceration Allamandin, allamcin, plumericin, isoplumericin, scoparone, scopoletin, pinoresinol [47]... 

Evergreen Scoparon, capillene, capillin, acute infectious hepatitis,... 

Artemisia capillaris Thunb. Scoparon, capillene, capillin, capillon, capillarin, capillanol.33 A choleretic, treat jaundice, acute infectious hepatitis, gallstone related illnesses. 

Methoxy psoralen and xanthotoxin were reported by Ceska et al. (1987). Zobel et al. (1991) isolated psoralen, bergapten, scoparon, scopoletin and seslin from the leaves of aniseed and Zobel and Brown (1991) isolated psoralen and bergapten from the fruit. 

SYNS AESCULETIN DIMETHYL ETHER 6,7-DLMETHOXYBENZOPYRAN-2-ONE 6,7-DIMETHOXYCOUMARIN ESCOPARONE ESCULETIN DIMETHYL ETHER SCOPARON SCOPARONE... 

T. heterotomum afforded the coumarin isofraxidin, 6,7,8-trimethoxycoumarin and 6 ,8 -dimethoxyfeselol [104]. T vulgare and T. parthenium contain scopoletin and isofraxidin [130]. T. ptarmicaeflorum afforded scopoletin and scoparone [12]. 

Among the coumarins isolated from species of Artemisia (Asteraceae), esculetin (6,7-dihydroxycoumarin) and its dimethyl-ether scoparone were known to be antiproliferative on vascular smooth muscle cells. This activity was further found in some very simple mono-substituted coumarins, which were even more potent than esculetin, although less effective. In an attempt to verify its mechanism of action, esculetin was tested for interactions with PTK and PKC. The induction of membrane PTK activity by either foetal calf serum or platelet-derived growth factor (PDGF) was moderately reduced by esculetin, whereas no effect was observed against PKC [56]. 

Stilbenoids from the roots of Vitis thunbergii displayed strong antiplatelet activity, such as (-)-viniferal (771), ampelopsin C, miyabenol A and (+)-vitisin C (700) [245]. Marchantinquinone exerted antiplatelet effects by inhibiting phosphoinositide turnover [514]. Antiplatelet aggregation activities have also been reported for piceid [390,515], rhaponticin [515] gigantol, moscatilin, scoparone and scopoletin [92]. 

Figure 8 Affinity chromatography for the analysis of the methanol extract of Artemisia capillaris under optimized conditions. SCO, scoparone CAP, capillarisin. Experimental conditions the column used was of 150 mm x 4.6 mm ID packed with HSA immobilized on silica (7 pm), column temperature was 35 °C, flow rate was 0.8ml min-1, and UV detection wavelength was set to 238 nm. Initially, 10 min isocratic elution with mobile phase of 1.5% acetonitrile in 10 mmol I-1 phosphate buffer (pH 6.0) then, 5 min linear gradient elution from 1.5 to 12% acetonitrile in 10 mmol I-1 phosphate buffer (pH 6.0) with the elution of the latter mobile phase kept for an additional 45 min and finally, another 45 min linear gradient elution from 12% acetonitrile in 10 mmol I-1 phosphate buffer (pH 6.0) to 15% acetonitrile in 10 mmol I-1 phosphate buffer (pH 7.4). Reproduced from H. L. Wang H. F. Zou J. Y. Ni L. Kong S. Gao B. C. Guo, J. Chromatogr. A 2000, 870, 501-510.

Capillarisin Cirsimaritin Rhamno-citrin Artemisia Capillari Spica/Compositae Whole plant Three flavonoids and two coumarins, scoparone and scopoletin, were isolated from the ethyl acetate extract of A. capillari. These compounds have been tested for their inhibitory effect on bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Increased aldose reductase activity and platelet aggregation are considered as two causes of diabetic complications. Capillarisin exhibited a potent inhibitory effect on bovine-LAR. Scoparone showed strong inhibitory effect on rabbit platelet aggregation [25],... 

Solatium dasyphyllum Schum. e( Thonn. Solanaceae Nig fruit anticonvulsant + ethanolic ext. scopoletin and scoparone (42 43) 156... 

For isolation of hydroxycoumarins the TE1 was subjected to liquid vacuum chromatography (LVC) with PE, CHC13, EtOAc and MeOH to yield the corresponding fractions [10]. No coumarins were found in the PE fraction. The CHCI3 fraction was chromatographed over a silica gel column with a dichloroethane (DCE) - MeOH gradient. A TLC study of the DCE fractions on silica gel yielded the coumarins esculetin (2), fraxetin (4), scoparone (6), isoscopoletin (7), scopoletin (8), fraxidin (9) and fraxinol (10). Identification of all coumarins was achieved by UV, IR, H NMR and mass spectra, and direct comparison with authentic samples. NOE experiments confirmed the structures of 9 and 10. 

Isoscopoletin (7), a 7- methyl derivative of esculetin is less inhibitory than esculetin itself, while scoparone (6), a 6,7-dimethyl derivative of esculetin, is completely inactive. The 7-O-methylesculin (11) and 6,7,8-trimethoxycoumarin (12) are totally deprived of activity. Evidently, a methylation of the phenolic OH decreases the activity. 

Seven hydroxycoumarins were further tested at a single concentration (5.0x1 O 4 M) for their ability to influence Cl and C3 functional activities after preincubation with undiluted NHS. 7-Methylesculin (11) had a good effect on reducing total, Cl, and C3 hemolysis via both pathways. Scoparone (6) strongly inhibited C3 alternative activity but in the case of the classical pathway only the total hemolysis was diminished without influence on Cl and C3. Esculin (1) slightly increased C3 classical activity but caused exhaustion of alternative C3 activity. 

Curcumin has demonstrated anti-inflammatory and anti-oxidant properties and it is essentially non-toxic (2-6). Recent studies have indicated that a group of four ingredients, which include curcumin, scoparone, ferulic acid and flavone of Matricaria L. has demonstrated marked hyperlipidemia and plateleC-aggrcgation reducing properties (7). 

Immunosuppressive Scoparone (27) Maybe caused by inhibition of tyrosine kinase [218,219]... 

Lens aldose reductase (bovine-LAR) inhibition Scoparone (27) and scopoletin (42) Isolated from Artemisia capillari and tested on bovine en me [221]... 

Platelet aggregation inhibition Osthole (28), cloricromene, scoparone (27) and scopoletin (42) Perhaps prevented thromboxane generation and phosphoinositide turn over [221,224,2 25]... 

Vasodilator Scoparone (27), scopoletin (42) Maybe mediated through radical scavenging effect thus potentiating c-GMP-mediated effects of internal nitric oxide [217,235]... 

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