Esculetin dimethyl ether

Zanthoxylum schinifolium Sieb. et Zucc. Hua Jiao (Pepper) (pericarp) Estragol, citronellol, phellandrene, xanthoxylene, skimmianine, magnoflorine, xanthoplanine, dictamnine, bergapten, berberine, esculetin dimethyl ether.33 48-53 Treat ascaris, relieve abdominal pain caused by ascariar obstruction. 

SYNS AESCULETIN DIMETHYL ETHER 6,7-DLMETHOXYBENZOPYRAN-2-ONE 6,7-DIMETHOXYCOUMARIN ESCOPARONE ESCULETIN DIMETHYL ETHER SCOPARON SCOPARONE... 

Among the coumarins isolated from species of Artemisia (Asteraceae), esculetin (6,7-dihydroxycoumarin) and its dimethyl-ether scoparone were known to be antiproliferative on vascular smooth muscle cells. This activity was further found in some very simple mono-substituted coumarins, which were even more potent than esculetin, although less effective. In an attempt to verify its mechanism of action, esculetin was tested for interactions with PTK and PKC. The induction of membrane PTK activity by either foetal calf serum or platelet-derived growth factor (PDGF) was moderately reduced by esculetin, whereas no effect was observed against PKC [56]. 

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