Antiplatelet aggregation activity

Related work described the synthesis of pyrrolo[3,2-c] azepines (eg. 25) as 5-HT2 antagonists and their antiplatelet aggregation activity . 

Sheen, W.-S., Tsai, I.-L., Teng, C.-M., Ko, F.-N. and Chen, I.-S. 1996. Indolopy-ridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifolium. Planta Medica, 62 175-176. 

Stilbenoids from the roots of Vitis thunbergii displayed strong antiplatelet activity, such as (-)-viniferal (771), ampelopsin C, miyabenol A and (+)-vitisin C (700) [245]. Marchantinquinone exerted antiplatelet effects by inhibiting phosphoinositide turnover [514]. Antiplatelet aggregation activities have also been reported for piceid [390,515], rhaponticin [515] gigantol, moscatilin, scoparone and scopoletin [92]. 

Mizuno, A., Inomata, N., Miya, M., Kamel, T., Shibata, M., Tatsuoka, T., Yoshida, M., Takiguchi, C., Miyasaki, T., 1999. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem. Pharm. Bull. 47 (2), 246-256. 

It is well known that platelets play an important role in the hemostatic process, and their aggregation can lead to arterial thrombosis [94]. Therefore, evaluation of compounds with antiplatelet aggregation activity... 

Antiplatelet Aggregation Activity. Alkaloids from Annonaceous plants were reported to inhibit platelet aggregation. According to our previous studies, more than twenty compounds were examined and most of the alkaloids were found inhibiting arachidonic acid (A.A) induced platelet aggregation [41]. Phenanthrene-alkaloids inhibited platelet aggregation initiated by four inducers (arachidonic acid, PAF, collagen, and thrombine)... 

Table 25. Antiplatelet aggregation activity of compounds Isolated from Aristolochia...

Orsini, F., Pelizzoni, F., Verotta, L., Abmjai, T., and Rogers, C.B., Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds, / Nat Prod., 60 (11), 1082-1087,1997. 

Of 75 compounds isolated from yin-chen wormwood, 15 showed antiplatelet aggregation activity (Wu et al. 2001). 

Chen KS, Chang YL, Teng CM, Chen CF, Wu YC. Furoquinolines with antiplatelet aggregation activity from leaves of Melicope confuse. Planta Med 2000 66 80-1. 

There is also a need to assess the role of the colonic microflora in the overall bioavailability and potential bioactivity of dietary flavonoids. The amoxmt of absorption of colonic metabolites is unclear at this time, and there is growing interest in the potential effects of the phenolic acids and their derivatives as potentially beneficial agents. For example, thehumanintestinalbacteriametabolites of rutin and quercetin, 3,4-dihydroxyphenylacetic acid, and 4-hydroxyl-phenyl-acetic acid have been shown to possess more effective antiplatelet aggregation activity than ratin and quercetin [107]. Furthermore, 2,4,6-trihydroxybenzaldehyde and quercetin were more effective than rutin in their cytotoxicity against tumor cell lines. The effects the phenolics themselves have on the microflora are an emerging field, and it is possible that a flavonoid-induced change in the rich colonic bacterial population may have an influence on the overall health of the individual. 

Quercetin (39) is one of the most common natural occmring flavonoids and is fonnd in many fiuits and vegetables, snch as apples and onions. It is well known for its antiinflamma-toiy, antioxidant, and antiplatelet aggregation activities [89, 91]. Quercetin can induce a wide spectrum of cellular events by interacting with a... 

Regulatory Status. GRAS ( 182.20). Onion is the subject of a positive German therapeutic monograph, indicated for antibacterial, Upid lowering, blood pressure lowering, and antiplatelet aggregation activity. ... 

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