Boston Collaborative Drug Surveillance Program

Greenblatt DJ, Shader RI, Koch-Weser J Psychotropic drug use in the Boston area a report from the Boston Collaborative Drug Surveillance Program. Arch Gen Psychiatry 32 518-521, 1975... 

In a report from the Boston Collaborative Drug Surveillance Program, pediatric nurses have reported a much higher frequency of complications from IM injections than that observed in the adult population. Twenty-three percent of pediatric nurses surveyed had observed complications (local pain, abscess, hematoma) versus a rate of 0.4% reported in adult patients [86]. Serious complications, such as paralysis from infiltration of the sciatic nerve, quadriceps myofibrosis, and accidental intra-arterial injection, are usually the... 

Boston Collaborative Drug Surveillance Program. Reserpine and breast cancer. Lancet 1974 2 669-71. 

Morrison AS, Jick H, Ory HW. Oral contraceptives and hepatitis. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Lancet 1977 l(8022) 1142-3. 

In the Boston Collaborative Drug Surveillance Program study mentioned above (18), the localization of bleeding, expressed in percentages and broadly classified as major/... 

In the Boston Collaborative Drug Surveillance Program study mentioned above, the peak incidence of bleeding was on the third day after the start of heparin therapy, which suggests a relatively safe initial 48-hour period in systemic heparinization (18). However, bleeding can be expected at any time during therapy, if the dosage becomes excessive or if susceptibility factors, such as trauma, intervene. 

In the Boston Collaborative Drug Surveillance Program study mentioned above, bleeding correlated with aspirin treatment, with sex, and probably with age and renal function (18). A meta-analysis of randomized trials reported that those aged over 70 are associated with the risk of major bleeding (22). Recent surgery or trauma also increase the risk. 

Cohen IS, lick H, Cohen SI. Adverse reactions to quinidine in hospitalized patients findings based on data from the Boston Collaborative Drug Surveillance Program. Prog Cardiovasc Dis 1977 20(2) 151-63. 

Nausea and vomiting are more common with spironolactone than with other diuretics (SED-9, 358) and were reported in 11% of patients in the Boston Collaborative Drug Surveillance Program (8). These symptoms can be reduced in patients taking high doses by spreading the dose out during the day. 

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