Schedules of controlled drugs

Appendix Vaccines, Immune Globulins, Other Complex Biologic Products Schedule of Controlled Drugs... 

Basic and Clinical Pharmacology > Schedule of Controlled Drugs > ... 

AccessMedicine Print Schedule of Controlled Drugs Diethylpropion (Tenuate)... 

Although development of psychological dependence and permanent psychic damage cannot be considered established sequelae of chronic use of psychotomimetics, the manufacture and commercial distribution of these drugs are prohibited (Schedule I, Controlled Drugs). 

There are many synthetic methods developed and reported for the preparation of LSD. All of them start with lysergic acid, and for that reason it has been listed as a Schedule III controlled drug, as a depressant, under Federal law. The amide lysergamide, a component of several varieties of morning glory seed, is also a controlled drug and, by law, a depressant. The earliest syntheses of LSD involved the used of an azide intermediate (the original Hofmann process,... 

The World Health Organization classified dextromethorphan as a non-analgesic, non-addictive substance in the late 1960s. In 1970, the Controlled Substance Act further added weight to this notion that dextromethorphan is not in the same class of drugs as its opiate forbearers in its abuse potential. This led to the decision of the DEA to leave dextromethorphan off its schedules of controlled substances. 

The Drug Enforcement Administration (DEA) and Food and Drug Administration (FDA) are aggressively monitoring the use and abuse of dextromethorphan. It is conceivable that dextromethorphan could be first classified as a drug obtainable only with a prescription. Furthermore, the DEA could place dextromethorphan on one of its schedules of controlled substances, which would force physicians, pharmacists, nurses, and hospitals to record the administration of the drug. At this stage, the former is far more likely than the latter since it has not been proven that dextromethorphan is an addictive substance. 

The present modeling approach to circadian cancer chronotherapy is based on an automaton model for the cell cycle. Continuous approaches to cell cycle progression have also been used to study the link between cell proliferation and circadian rhythms [44] and to determine, in conjunction with optimal control theory, the most efficient circadian schedules of anticancer drug administration [45]. Including more molecular details of the cell cycle in continuous models for cell populations represents a promising line for future research. Hybrid models incorporating molecular details into the automaton approach presented here will also likely be developed. 

U.S. Food and Drug Administration (schedules of controlled substances)... 

Additional controls are placed on the sale or supply of certain medicines that are defined as controlled drugs by the Misuse of Drugs Act 1975. These drugs are listed in the Schedules to the Act. The Act defines three clzisses of controlled drugs— Class A, Class B (further subdivided into Parts I, II III) and Class C (further subdivided into Parts I to VII). Controls imposed by the Misuse of Drugs Act are in addition to those imposed by the Medicines Act 1981. 

An indication as to the prescriber type. On an NHS prescription form, the prescriber type is clearly identifiable. However, non-NHS (private) prescriptions will not be on specific prescription forms (except the private prescribing of Schedule 2 and Schedule 3 controlled drugs - see Section 6.3.3). Therefore, the identification of the prescriber is not always obvious. There needs to be something on the prescription to identify the prescriber type and usually, this will be the prescriber s qualifications (e.g. MB ChB - see Appendix 1). 

Unlike NHS prescription supply (see Section 3.3.8), the patient or the patient s representative will pay you for the entire cost of the medication (plus a mark-up cost and dispensing fee charged by the pharmacy to cover their costs). Therefore, non-NHS (private) prescription forms do not need to be sent off to the NHS Business Services Prescription Pricing Division (or equivalent) for reimbursement at the end of each month (except with the private prescribing of Schedule 2 and Schedule 3 controlled drugs see Section 6.3.3). 

It is good practice to make an entry in the prescription-only medicines register at the time of supply it is only a good practice requirement as the requisition will be retained within the pharmacy for two years from the date of supply (the exception to this is for Schedule 2 and Schedule 3 controlled drugs see Section 6.3.6). However, if the request for the supply of a prescription-only medicine (POM) was an oral request (see Section 5.3) the prescription-only medicines register entry would be a legal requirement (as there is no paper requisition detailing the sale to keep for two years). 

Although controlled drugs are dealt with in Chapter 6, for completeness, it is worth mentioning midwives supply orders here. Midwives supply orders are needed for the lawful supply of certain controlled drugs to a midwife from a pharmacist (i.e. those items listed above that are Schedule 2 or Schedule 3 controlled drugs diamorphine, morphine, pentazocine and pethidine). They are not required for the supply of other listed prescription-only medicines. 

For day-to-day use in pharmacy, the classification of controlled drugs into different schedules is used. The schedules reflect more the use of the individual controlled drugs within medicine and is more useful. These schedules are set out in the Misuse of Drugs Regulations ... 

It is worth noting that although it is a Schedule 3 controlled drug, some of the requirements listed above do not apply to prescriptions for the drug temazepam. 

The validity of prescriptions for controlled drugs has been reduced from 13 weeks to 28 days. The 28 days is from the date the prescription was signed or from the specified start date (see instalment dispensing for addicts (Section 6.3.5)) and applies to Schedule 2, Schedule 3 and Schedule 4 controlled drugs. 

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