Scale identification

Mawuenyega, K.G., Kaji, H., Yamuchi, Y., Shinkawa, T., Saito, H., Taoka, M., Takahashi, N., Isobe, T. (2003). Large-scale identification of Caenorhabditis elegans proteins by multidimensional liquid chromatography—tandem mass spectrometry. J. Proteome Res. 2, 23-35. 

Diehn M et al. Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. Nature Genet 2000 25 58-62. 

Wang DG, Fan JB, Siao CJ et al. Large-scale identification, mapping, and geno-typing of single-nucleotide polymorphisms in the human genome. Science 1998 280 1077-1082. 

Wang, D.G., et al., "Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome," Science 280, 1077-1082 (1998). 

Fomenko, D.E., Xing, W., Thomas, D.J. and Gladyshev, V.N. (2007) Large-scale identification of catalytic redox-active cysteines by detecting sporadic cysteine/selenocysteine pairs in homologous sequences. Science, 315, 387-89. 

M Fountoulakis, J-F Juranville, P Berndt. Large-scale identification of proteins of Haemophilus influenzae by amino acid composition analysis. Electrophoresis 18 ... 

A Shevchenko, ON Jensen, AV Podtelejnikov, F Sagliocco, M Wilm, O Vorm, P Mortensen, A Shevchenko, H Boucherie, M Mann. Linking genome and proteome by mass spectrometry large-scale identification of yeast proteins from two dimensional gels. Proc Natl Acad Sci (USA) 93 14440-14445, 1996. 

Knuth, K. et al. 2004. Large-scale identification of essential Salmonella genes by trapping lethal insertions. Mol. Microbiol. 51, 1729-1744. 

This creates the need for the selective isolation of specific enz.yr.ies on a technical scale. Identification, purification and molecular characterization of technological relevant enzymes are necessary for improving or blocking their synthesis by genetic manipulation. 

A. Shevchenko, O.N. Jensen, A.V. Podtelejnikov, F. Sagliocco, M. Wilm, O. Vorm, P. Mortesen, A. Shevchenk, H. Boucherie, M. Mann, Linking genome and proteome by MS large-scale identification of yeast proteins from 2D-GE, PNAS, 93 (1996) 14440. 

K.G. Mawuenyega, H. Kaji, Y. Yamauchi, T. Shinkawa, H. Saito, M. Taoka, N. Takahashi, T. Isobe, Large-scale identification of C. elegans proteins by multidimensional LC-MS-MS, J. Proteome Res., 2 2003) 23. 

Shevchenko, A. Jensen, O.N. Podtelejnikov, A.V. Sagliocco, F Wilm, M. Vorm, O. Mortensen, P Shevchenko, A. Boucherie, H. Mann, M. Linking Genome and Pioteome by Mass Spectrometry Large-Scale Identification of Yeast Proteins from Two Dimensional Gels, Proc. Natl. Acad. Sci. USA 93, 14440-14445 (1996). 

Arifuzzaman, M. et al. 2006. Large-scale identification of protein-protein interaction of E. ColiK12. Genome Biol. 16, 686-691. 

Bondoc, D. C., Hall, J., Zhong, W. W., Sdicu, A. M., Davies, J., Klis, F. M., Robbins, P. W., and Bussey, H. (1997). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147, 435-450. 

Lectins and antibodies provide selective means to enrich subsets of glycoproteins from complex mixtures (Figure 18(a)). For example, lectin-affinity chromatography enabled the large-scale identification ofN-linked glycoproteins from complex mixtures by Alternatively, the availability of specific antibodies toward [3-... 

Proteomics is the large-scale analysis of proteins and constitutes a valuable tool for understanding gene function. Proteomics deals mainly with protein microchaiacterization for large-scale identification of proteins and their post-translational modifications, differential-display proteomics for comparison of protein levels with potential application in a wide range of diseases and studies of protein-protein interactions using techniques such as... 

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