Scaffolds biomaterial-based

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Biomaterials-Based Scaffolds as Depots and Controlled-Release sterns... 

Biomaterial-based 3D systems have been the most influential tools in rendering a scaffold to cells, both in culture and inside the body. Scaffolds used for tissue engineering perform many functions, and their role during tissue formation is dependent on the specific characteristics of the selected biomaterials. It has been proven that 3D scaffolds enhance osteogenic, haematopoietic, neural and chondrogenic differentiation. 

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Zhou M, Smith AM, Das AK et al (2009) Self-assembled peptide-based hydrogels as scaffolds for anchorage-dependent cells. Biomaterials 30 2523-2530... 

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Lyons, F. G., Al-Munajjed, A. A., Kieran, S. M., Toner, M. E., Murphy, . M., Duffy, G. P., and O Brien, F. J. (2010). The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs. Biomaterials 31, 9232-9245. 

Abstract Carbohydrates have been investigated and developed as delivery vehicles for shuttling nucleic acids into cells. In this review, we present the state of the art in carbohydrate-based polymeric vehicles for nucleic acid delivery, with the focus on the recent successes in preclinical models, both in vitro and in vivo. Polymeric scaffolds based on the natural polysaccharides chitosan, hyaluronan, pullulan, dextran, and schizophyllan each have unique properties and potential for modification, and these results are discussed with the focus on facile synthetic routes and favorable performance in biological systems. Many of these carbohydrates have been used to develop alternative types of biomaterials for nucleic acid delivery to typical polyplexes, and these novel materials are discussed. Also presented are polymeric vehicles that incorporate copolymerized carbohydrates into polymer backbones based on polyethylenimine and polylysine and their effect on transfection and biocompatibility. Unique scaffolds, such as clusters and polymers based on cyclodextrin (CD), are also discussed, with the focus on recent successes in vivo and in the clinic. These results are presented with the emphasis on the role of carbohydrate and charge on transfection. Use of carbohydrates as molecular recognition ligands for cell-type specific dehvery is also briefly... 

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