SC-PL method

Zhang et al. [160] prepared a 3D porous scaffold with the composite of PLGA and PLLA-grafted nanoHAp using a SC/PL method. They revealed that the nanoparticles of g-HAp distributed on the surface of PLGA matrix more uniformly than that of ungrafted HAP. Moreover, the intramuscular implant study showed that... 

Fig. 16 (a) Exposure of HAp nanopaiticles to the surface of scaffolds fabricated by the GF/PL and SC/PL methods, (b) Fabrication of PLGA/HAp composite scaffolds with the GF/PL method. Adapted from [159]... 

The lack of control over pore size is a major issue for methods such as fiber bonding, but solvent casting and particulate leaching (SC-PL) allows for fine control over pore... 

Solvent casting and particulate leaching (SC/PL) is a simple and commonly used method for fabricating scaffolds for tissue engineering. With an appropriate thermal treatment, porous constructs of synthetic biodegradable polymers can be prepared with specific porosity, surfaceivolume ratio, pore size and crystallinity for different applications. This method involves mixing water-soluble salt (e.g. sodium chloride, sodium citrate) particles into a polymer solution. The mixture is then cast into the mould of the desired shape. After the solvent is removed by evaporation or lyophilization, the salt particles are leached out to obtain a porous structure with the pore shape limited to the cubic crystal shape of the salt. Removal of soluble particles from the interior of a polymer matrix is difficult and limits the thickness of the films prepared to ca. 2 mm [293]. 

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