Sample Acute Toxicity Tests and Commonly Used Species

Type of Test Oral Toxicity (LDjij) Dermal Toxicity Inhalation Toxicity Eye Irritation Skin Irritation Skin Sensitization Delayed Neurotoxicity  

LD5Q = Lethal dose resulting in death of 50% of tested animals. Typically conducted on organophosphate insecticides. 

Changes in rate and depth of breathing Changes in locomotive functions Onset of convulsions Impaired reflexes Abnormal excretion 

This additional information can help identify nonlethal toxic effects that increase the utility of the test. 

The LD50 typically applies only to the oral route of administration (e.g., water or diet). For tests involving inhalation, LC50 values cu e identified. The LC50 is defined as the concentration of a compound in air that causes death in 50 percent of test animals over a specified time period. For aquatic species, LC50 values are also used however, in this case the values represent surface water concentrations. 

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Table 5.2. Sample Acute Toxicity Tests and Commonly Used Species...

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