Salmonella typhi, inhibition

The diazo group confers a broad spectrum of activity on the 2-substi-tuted indoles. In fact, 3-diazo-2-substituted indoles are effective against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi and Proteus vulgaris bacteria (65MI1), and 3-diazo-2-ethoxycarbo-nylindole inhibits sarcoma 180 in mice and rats (83KFZ1183). 

PHARMACOLOGICAL ACTIVITIES AND CLINICAL TRIALS Antibacterial activity. Alcohol extract of black tea, assayed on Salmonella typhi and Salmonella paratyphi A, was active on all strains of Salmonella paratyphi A, and only 42.19% of Salmonella typhi strains were inhibited hy the extract ". Ffot water extract of the dried entire plant and the tannin fraction, on agar plate, were active on Escherichia coli. Pseudomonas aeruginosa, and Staphylococcus aureus. ... 

Though the antibacterial effects of COS in the above experiments were lower than the chitosan, chitooligosaccharides have also shown the capability of inhibiting the growth of bacteria, including Salmonella Typhi, S. aureus, and lactic acid bacteria (Jeon et al., 2001). These researches further stated that the COS with molecular weight over 10,000Da is required for the effective antibacterial... 

The quantity of capsular polysaccharide is apparently of importance in a variety of pathogens. Klebsiella pneumoniae. Salmonella typhi, 5. typhi-murium, E. coli. Streptococcus pneumoniae and Staphylococcus aureus have all been reported to show a relationship between the amount of capsular material and virulence, resistance to phagocytosis, or resistance to humoral host defences. It has been suggested in the case of E. coli that the amount of K-antigen, as measured by its ability to coat red blood cells and inhibit their aggregation by haemagglutinating antiserum, is the most important factor determining resistance to the complement-mediated bactericidal activity of serum. Other studies have found evidence that the type of capsular polysaccharide may be more important. 

Alcohol and aqueous extracts of various plant parts of E. cardamomum inhibited the in vitro growth of a human pathogenic strain of Salmonella typhi ... 

Evocarpine, 1 -methyl-2-[(Z)-tridec-7-enyl]quinolin-4(lH)-one, 1 -methyl-2-undecylquinolin-4(lH)-one, dihydroevocarpine, 1 -methyl-2-pentadecylquinolin (lH)-one, l-methyl-2-[(4Z,7Z)-tridec-4,7-dienyl]quinolin-4(lH)-one, and 1-methyl-2-[(6Z,9Z)-pentadec-6,9-dienyl]quinolin-4(lH)-one from Euodia ruticarpa (Table ID showed strong antibacterial activity against H. pylori, both in vitro and in vivo, by inhibiting respiration. The results reinforced previous indications of this class of alkaloids as novel, potential therapeutic agents for the treatment of ulcers, as shown above with the alkaloids from microbial sources (68,241-243). The related alkaloids l-methyl-2-n-nonylquinolin-4(lH)-one, 2-M-nonylquinolin-4(lH)-one, and l,2-dimethyl-quinolin-4(lH)-one from Boronia (Table II) showed mild to moderate activities against B. subtilis, S. aureus, Sarcina lutea, exterotoxigenic E. coli. Salmonella typhi, and Klebsiella sp. (244). 

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